{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:35:16Z","timestamp":1761708916450,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In the northeast of Brazil, caprine arthritis\u2010encephalitis (CAE) is one of the key reasons for herd productivity decreasing that result in considerable economic losses. A comparative study was carried out using computed radiography (CR), histological analysis (HA), and scanning electronic microscopy (SEM) of the joints of CAE infected and normal goats. Humerus head surface of positive animals presented reduced joint space, increased bone density, and signs of degenerative joint disease (DJD). The carpal joint presented no morphological alterations in CR in any of the animals studied. Tarsus joint was the most affected, characterized by severe DJD, absence of joint space, increased periarticular soft tissue density, edema, and bone sclerosis. Histological analysis showed chronic tissue lesions, complete loss of the surface zone, absence of proteoglycans in the transition and radial zones and destruction of the cartilage surface in the CAE positive animals. Analysis by SEM showed ulcerated lesions with irregular and folded patterns on the joint surface that distinguished the limits between areas of normal and affected cartilage. The morphological study of the joints of normal and CAE positive goats deepened understanding of the alteration in the tissue bioarchitecture of the most affected joints. The SEM finding sustained previous histological reports, similar to those found for rheumatoid arthritis, suggesting that the goat infected with CAE can be considered as a potential model for research in this area. <jats:italic>Microsc. Res. Tech. 77:11\u201316, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jemt.22306","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T21:07:21Z","timestamp":1383599241000},"page":"11-16","source":"Crossref","is-referenced-by-count":5,"title":["Comparative study by computed radiography, histology, and scanning electron microscopy of the articular cartilage of normal goats and in chronic infection with caprine arthritis\u2010encephalitis virus"],"prefix":"10.1002","volume":"77","author":[{"given":"Videlina Rodrigues","family":"de Sousa","sequence":"first","affiliation":[{"name":"Animal Science Post\u2010Graduate Program Federal University of Piau\u00ed (UFPI) Teresina Piau\u00ed Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"das Chagas Ara\u00fajo Sousa","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science State University of Piau\u00ed (UESPI) 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Macedo","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and surgery Federal University of Piau\u00ed (UFPI) Teresina Piau\u00ed Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"de Jesus Moraes Junior","sequence":"additional","affiliation":[{"name":"Animal Science Post\u2010Graduate Program Federal University of Piau\u00ed (UFPI) Teresina Piau\u00ed Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio","family":"Ribeiro Alves","sequence":"additional","affiliation":[{"name":"Department of Veterinary Morphophysiology Federal University of Piau\u00ed (UFPI) Teresina Piau\u00ed Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"257","article-title":"A pathogenetic study of the early connective tissue lesions of viral caprine 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