{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T20:54:34Z","timestamp":1761252874706,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The effects of anti\u2010angiogenic therapies in guiding tumor angioarchitecture prompted us to examine the modifications in the vascular network of the oral squamous cell carcinoma (SCC) produced by the multitargeted tyrosine kinase inhibitor sunitinib malate. Twelve Syrian hamsters had their right buccal pouches submitted to tumor induction with dimethylbenzanthracene and carbamide peroxide for 55 days. The animals were then divided into two groups of six animals each; group I was treated with sunitinib malate and group II (control) was remained untreated. After 4 weeks, the hamsters had their vascular networks casted by Mercox<jats:sup>\u00ae<\/jats:sup> resin and analyzed by scanning electron microscopy. The qualitative study of the vascular network of the control tumor\u2010bearing pouches showed images of intussusception and sprouting angiogenesis, flattened blood vessels, abrupt variations in their diameter, and a tortuous course. The samples treated with sunitinib exhibited a qualitative reduction of the signs of vascular proliferation. In addition, these casts presented an attenuation of the morphological features observed in the untreated tumor\u2010bearing pouches. Quantitative analysis demonstrated that the pouches treated with sunitinib did not show a decrease (<jats:italic>P<\/jats:italic> &gt; 0.05) in the vascular diameter and intervessel distances when compared with the control group. The results of the present study suggest that sunitinib may act on the vascular network of oral SCC, normalizing the blood vessels. However, further experiments should be performed in order to determine a judicious dose of this anti\u2010angiogenic therapy. <jats:italic>Microsc. Res. Tech. 77:250\u2013256, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jemt.22336","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T23:52:57Z","timestamp":1390521177000},"page":"250-256","source":"Crossref","is-referenced-by-count":6,"title":["The effect of the anti\u2010angiogenic drug sunitinib malate on the vascular architecture of oral squamous cell carcinoma"],"prefix":"10.1002","volume":"77","author":[{"given":"Vin\u00edCius Faccin","family":"Bampi","sequence":"first","affiliation":[{"name":"Department of Surgery, Medical School Pontifical Catholic University of Rio Grande do Sul Av. Ipiranga, 6681, Porto Alegre\/RS, CEP: 90619\u2010900 Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Ferreira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Morphological Science, Medical School Federal University of Pelotas Av. Duque de Caxias 250, Pelotas\/RS, CEP: 95030\u2010001 Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Beatriz Oliveira","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Department of Morphological Science Federal University of Pelotas Av. Duque de Caxias 250 (Pr\u00e9dio Morfologia), Pelotas\/RS, CEP: 95030\u2010001 Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jefferson Luis Braga","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical School Pontifical Catholic University of Rio Grande do Sul Av. 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