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This presents another example of nephritis\u2010induced diaphragmed fenestrae in the renal glomerular endothelium. In addition, knot\u2010\/umbilicus\u2010like structures discrete from and larger than the central knots of regular diaphragms of fenestrated endothelium were clearly demonstrated to occur randomly in the renal glomerular endothelial fenestrae of mutant mice and wild ones. The knot\u2010structures were revealed to be protrusions of underlining basement lamina in conventional TEM by section\u2010tilting observation. <jats:italic>Microsc. Res. 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