{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:58:07Z","timestamp":1784912287029,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pregnancy\u2010related deep vein thrombosis (DVT) is most common during the late phase of pregnancy and the first 6\u2010weeks postpartum. Pregnancy\u2010related DVT can have long\u2010term complications, specifically post\u2010thrombotic syndrome (PTS). Fibrin network ultrastructure is altered during pregnancy and post\u2010partum. It is therefore essential to evaluate fibrin fiber diameter during and after pregnancy as this may provide insight into pregnancy\u2010related DVT and subsequent PTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The fibrin network ultrastructure of females during different phases of pregnancy was compared to that of non\u2010pregnant females to assess possible changes to the fibrin network morphology and fibrin fiber diameter using scanning electron microscopy micrographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fibrin network arrangement was more densely packed during different phases of pregnancy, corresponding to earlier findings. Fibrin diameter decreased significantly during pregnancy, with the greatest decrease occurring during the late phase of pregnancy. The fractal dimensions of fibrin micrographs increased significantly during pregnancy compared to nonpregnant females. These changes are indicative of a simultaneous hypercoagulable and hypofibrinolytic state and correspond to the increased risk of DVT and subsequent development of PTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is critical to identify \u201cvulnerable\u201d females with an inflammatory predisposition to prevent possible DVT and subsequent PTS. Modifiable risk factors like obesity and smoking should be addressed to alleviate the burden on the coagulation system. Morphological and viscoelastic techniques are crucial in assessing the coagulatory health of females during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jemt.22727","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T09:28:57Z","timestamp":1469179737000},"page":"959-965","source":"Crossref","is-referenced-by-count":6,"title":["Clinical relevance of fibrin fiber diameter during different phases of pregnancy"],"prefix":"10.1002","volume":"79","author":[{"given":"Albe C.","family":"Swanepoel","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine, Faculty of Health Sciences, University of Pretoria  South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12229"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fdfb11"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-05-0350"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6926(03)00021-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(02)00303-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116350"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"1991","article-title":"Pregnancy\u2010related mortality surveillance\u2014United States","volume":"52","author":"Chang J.","year":"2003","journal-title":"MMWR Surveillance Summary"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1354"},{"issue":"12","key":"e_1_2_6_10_1","first-page":"1357","article-title":"Coagulation assessment in normal pregnancy: Thrombelastography with citrated non activated samples","volume":"78","author":"Della Rocca G.","year":"2012","journal-title":"Minerva Anestesiologica"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","unstructured":"Dhillon P. K.&Adams M. J.(2013). Thrombosis in systemic lupus erythematosus: Role of impaired fibrinolysis (p434\u2013440).","DOI":"10.1055\/s-0033-1334484"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-11-0753"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181506ee5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0598"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10265-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.08.050"},{"issue":"2","key":"e_1_2_6_18_1","first-page":"240","article-title":"Maternal mortality in Sweden, 1980\u20131988","volume":"84","author":"H\u00f6gberg U.","year":"1994","journal-title":"Obstetrics & Gynecology"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.08.041"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.184127"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.11.037"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06200.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182652a33"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.04.007"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749691210100204"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1257"},{"issue":"3","key":"e_1_2_6_27_1","first-page":"115","article-title":"Novel pathway of ironinduced blood coagulation: Implications for diabetes mellitus and its complications","volume":"122","author":"Lipinski B.","year":"2012","journal-title":"Polish Archives of Medicine Wewnetrzej"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22047"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3253"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-009-0336-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02921.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2817-x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4ib00025k"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283468a0d"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1805-2"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084698"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.09.011"},{"key":"e_1_2_6_38_1","first-page":"17","article-title":"An evaluation method of ecotypes of japanese lawn grass (Zoysia japonica STEUD.) for three different ecological functions. Bull","volume":"49","author":"Sasaki H.","year":"1994","journal-title":"National Grassland Research Institute"},{"issue":"2","key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0308-2261(18)30021-3","article-title":"Fibrinogen, fibrin and fibrin degradation products in relation to atherosclerosis","volume":"15","author":"Smith E.","year":"1986","journal-title":"Clinics in Haematology"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01648.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0148-7"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22378"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22385"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.230631"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04690.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00034.x-i1"}],"container-title":["Microscopy Research and Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjemt.22727","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.22727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:06:19Z","timestamp":1760630779000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jemt.22727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/jemt.22727"],"URL":"https:\/\/doi.org\/10.1002\/jemt.22727","archive":["Portico"],"relation":{},"ISSN":["1059-910X","1097-0029"],"issn-type":[{"value":"1059-910X","type":"print"},{"value":"1097-0029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,22]]}}}