{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:09:19Z","timestamp":1769861359833,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean government (MSIP)","award":["2015R1A5A1037656"],"award-info":[{"award-number":["2015R1A5A1037656"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lasers and photodynamic therapy have been considered a convergence treatment for onychomycosis, which is a fungal infection on the nail bed and nail plate. Laser therapies have shown satisfactory results without significant complications for onychomycosis; however, the mechanism of clearing remains unknown. In this work, we investigated changes in the chemical structure of nail keratin induced by Nd:YAG laser using Raman spectroscopy. Toe nails with onychomycosis were treated with 1064 nm Nd:YAG laser. After laser treatment, the disulfide band (490\u2013590 cm<jats:sup>\u22121<\/jats:sup>) of nail keratin was rarely observed or was reduced in intensity. The amide I band (1500\u20131700 cm<jats:sup>\u22121<\/jats:sup>) also showed changes induced by the laser. The \u03b1\u2010helical (1652 cm<jats:sup>\u22121<\/jats:sup>) structures dominated the \u03b2\u2010sheet (1673 cm<jats:sup>\u22121<\/jats:sup>) in nontreated nail, but the opposite phenomenon was observed after laser treatment.<\/jats:p>","DOI":"10.1002\/jemt.22734","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T09:27:46Z","timestamp":1470216466000},"page":"338-343","source":"Crossref","is-referenced-by-count":12,"title":["Changes in nail keratin observed by Raman spectroscopy after Nd:YAG laser treatment"],"prefix":"10.1002","volume":"80","author":[{"given":"Min Kyung","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine, Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine, Kyung Hee University Seoul 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