{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:21:35Z","timestamp":1760660495229,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To gain insight to underlying mechanism of the formation of calcium carbonate (CaCO<jats:sub>3<\/jats:sub>) gallbladder stones, we did comparative study of stones with mud appearance and those with coralliform appearance. A total of 93 gallbladder stones with mud appearance and 50 stones with coralliform appearance were analyzed. The appearance, color, texture, and the detection of <jats:italic>Clonorchis sinensis<\/jats:italic> eggs by microscopic examination were compared between the two groups. Then, the material compositions of stones were analyzed using Fourier Transform Infrared spectroscopy and the spectrogram characteristics were compared. Moreover, microstructure characteristics of the two kinds of stones were observed and compared with Scanning Electron Microscopy. Mud\u2010like gallbladder stones were mainly earthy yellow or brown with brittle or soft texture, while coralliform stones were mainly black with extremely hard texture, the differences between the two groups was significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The analytic results of FTIR spectroscopy showed that 95.7% (89\/93) of the mud\u2010like gallbladder stones were CaCO<jats:sub>3<\/jats:sub> stones, and mainly aragonite; while all of the coralliform stones were CaCO<jats:sub>3<\/jats:sub> stones, and mainly calcite (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Meanwhile, microscopic examination indicated that the detection rate of <jats:italic>Clonorchis sinensis<\/jats:italic> eggs in mud\u2010like CaCO<jats:sub>3<\/jats:sub> stones was lower than that in coralliform CaCO<jats:sub>3<\/jats:sub> stones (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), and that in aragonite CaCO<jats:sub>3<\/jats:sub> stones was lower than that in calcite CaCO<jats:sub>3<\/jats:sub> stones(<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Mud\u2010like CaCO<jats:sub>3<\/jats:sub> stones mainly happened to patients with cystic duct obstruction. <jats:italic>Clonorchis sinensis<\/jats:italic> infection was mainly associated with coralliform (calcite) CaCO<jats:sub>3<\/jats:sub> stones. Cystic duct obstruction was mainly associated with mud\u2010like (aragonite) CaCO<jats:sub>3<\/jats:sub> stones.<\/jats:p>","DOI":"10.1002\/jemt.22857","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T10:55:41Z","timestamp":1488279341000},"page":"722-730","source":"Crossref","is-referenced-by-count":4,"title":["A comparative study of mud\u2010like and coralliform calcium carbonate gallbladder stones"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-5960","authenticated-orcid":false,"given":"Rui\u2010Hong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Sixth People's Hospital of Nansha  Guangzhou 511470 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Bing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Sixth People's Hospital of Nansha  Guangzhou 511470 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Sixth People's Hospital of Nansha  Guangzhou 511470 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Sixth People's Hospital of Nansha  Guangzhou 511470 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonics The Sixth People's Hospital of Nansha  Guangzhou 511470 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Qiang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Sixth People's Hospital of Nansha  Guangzhou 511470 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200012000-00008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35090573"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconhyd.2008.09.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.1.103"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm403497g"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i31.4215"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01721585"},{"key":"e_1_2_7_9_1","first-page":"418","article-title":"Rare gallstone (calcium carbonate calculus)","volume":"9","author":"Goto K.","year":"1996","journal-title":"Ryoikibetsu Shokogun Shirizu"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.4.374"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005524624411"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.3.316"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800968"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0682-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01439.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja907063z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2003.44.4.561"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-2-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/la503726y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196607000-00010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/0953-8984\/22\/22\/225402"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200206000-00012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-193902000-00001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-193110000-00003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja102439r"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3673472"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042471"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2014.06.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009959107"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112278"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","DOI":"10.1007\/BF02773585","article-title":"Review of five cases of limy bile e particularly on radiological, chemical and crystallographic studies","volume":"14","author":"Saito K.","year":"1979","journal-title":"Gastroenterologia Japonica"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9107-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1867-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.05.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp055063o"},{"issue":"3","key":"e_1_2_7_36_1","first-page":"223","article-title":"Mucinous cholangio\u2010carcinoma associated with Clonorchis sinensis infestation: A case report","volume":"10","author":"Shim H. S.","year":"2004","journal-title":"Korean Journal of Hepatology"},{"key":"e_1_2_7_37_1","first-page":"167","volume-title":"Methods in biliary research","author":"Soloway R. D.","year":"1995"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn900377d"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.02.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.05.022"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.159"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010635901414"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296436"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10942"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.08.010"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.22310"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.074"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2012.06.001"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004008"}],"container-title":["Microscopy Research and Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjemt.22857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.22857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:14:00Z","timestamp":1760624040000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jemt.22857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/jemt.22857"],"URL":"https:\/\/doi.org\/10.1002\/jemt.22857","archive":["Portico"],"relation":{},"ISSN":["1059-910X","1097-0029"],"issn-type":[{"type":"print","value":"1059-910X"},{"type":"electronic","value":"1097-0029"}],"subject":[],"published":{"date-parts":[[2017,2,28]]}}}