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The goal of our study was to investigate the cardiovascular effect of salusin\u2010\u03b2 microinjections into the rostral ventrolateral medulla (RVLM) in anesthetized rats and study their mechanism of action. Microinjection of the artificial cerebrospinal fluid (aCSF) into the RVLM did not affect the blood pressure (BP) or heart rate (HR) in anesthetized rats. Topical application of salusin\u2010\u03b2 into the RVLM produced a dose\u2010dependently increase of BP in anesthetized rats. Microinjection of higher dose salusin\u2010\u03b2 produced significant tachycardia. Prior application of the L\u2010NAME into the RVLM of rats did not alter the hypertension and tachycardia induced by intra\u2010RVLM salusin\u2010\u03b2. Notable, the cardiovascular functions elicited by intra\u2010RVLM salusin\u2010\u03b2 were significantly decreased by pretreatment with Nic, KYN and atropine. In conclusion, the present study shows that the hypertension and tachycardia induced by intra\u2010RVLM salusin\u2010\u03b2 might be partly mediated, at least in our opinion, by muscarinic receptors, glutamate receptors or L\u2010type calcium channels.<\/jats:p>","DOI":"10.1002\/jemt.22868","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T05:54:50Z","timestamp":1490680490000},"page":"812-819","source":"Crossref","is-referenced-by-count":3,"title":["The cardiovascular functions of salusin\u2010\u03b2 mediated by muscarinic receptors, glutamate receptors or L\u2010type calcium channels within the rostral ventrolateral medulla of rats"],"prefix":"10.1002","volume":"80","author":[{"given":"Fu\u2010Jia","family":"Xie","sequence":"first","affiliation":[{"name":"Department of General Surgery First Hospital of Lanzhou University 1 DongGang West Road Lanzhou 730000 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