{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:11:28Z","timestamp":1760631088117,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Organic silicon (OS), glucosamine sulfate (GS), and methylsulfonylmethane (MSM) have been related to bone and connective tissue health and have been considered as basic therapy for osteoarthrosis disorders. Therefore, the aim was to analyze the effect of the association of these three components in mandibular bone defects in rats. Nine rats were used for histocompatibility test. In each animal was implanted the composition (70% OS, 15% GS, 15% MSM) and gutta percha (control) under the dorsal subcutaneous tissue. The samples were collected at 7, 14, and 21 days post\u2010surgery and inflammatory events analyzed. In sequence, the composition was engrafted in mandibular bone defects of nine rats; bone defects without treatment were the control group. Analyses were performed at 7, 14, and 28 days post\u2010surgery and samples were evaluated by scanning electron microscopy (SEM). For the histocompatibility test, both groups had a moderate inflammatory process at 7 days post\u2010surgery and mild inflammatory process at 14 and 21 days. But in SEM analysis, the composition promotes an extensive reabsorption in cortical and crest alveolar bone, and great tooth root reabsorption. In conclusion, although the composition had positive result in the histocompatibility test, its direct application in mandibular bone defects caused intense resorption.<\/jats:p>","DOI":"10.1002\/jemt.22911","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T07:29:42Z","timestamp":1501226982000},"page":"1161-1166","source":"Crossref","is-referenced-by-count":5,"title":["Effect of organic silicon, methylsulfonylmethane, and glucosamine sulfate in mandibular bone defects in rats"],"prefix":"10.1002","volume":"80","author":[{"given":"Fl\u00e1via Santiago","family":"de Sousa Rosa","sequence":"first","affiliation":[{"name":"Dentistry UnderGraduate Program, Federal University of Santa Catarina CEP: 88040\u2010970 Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fabia Teodoro","family":"Stuepp","sequence":"additional","affiliation":[{"name":"Dentistry Graduate Program Federal University of Santa Catarina CEP: 88040\u2010970 Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Modolo","sequence":"additional","affiliation":[{"name":"Pathology Department and Dentistry Graduate Program Federal University of Santa Catarina CEP: 88040\u2010970 Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-9940","authenticated-orcid":false,"given":"Michelle Tillmann","family":"Biz","sequence":"additional","affiliation":[{"name":"Morphology Sciences Department and Dentistry Graduate Program Federal University of Santa Catarina CEP: 88040\u2010970 Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00066"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000087983.28957.5D"},{"key":"e_1_2_6_4_1","first-page":"504","article-title":"Glucosamine sulphate: A controlled clinical investigation in arthrosis","volume":"2","author":"D'Ambrosio E.","year":"1981","journal-title":"Pharmatherapeutica"},{"key":"e_1_2_6_5_1","first-page":"1838","article-title":"Increased silicon levels in dialysis patients due to high silicon content in the drinking water, inadequate water treatment procedures, and concentrate contamination: A multicentre study","volume":"10","author":"D'Haese P. 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