{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:21:02Z","timestamp":1790882462632,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Different types of metal oxide nanoparticles (NPs) have been suggested for various applications such as water treatment and construction of agricultural pesticides; however, there are concerns about the potential toxicity of these compounds for the nontarget organism especially aquatic organisms. The aims of this study were assessing toxicity and histopathological effects of copper oxide NPs (NPs\u2010CuO) on common carp (<jats:italic>Cyprinus carpio<\/jats:italic>) as a model organism. For this purpose 150 common carp with an average weight 7\u2009\u00b1\u20091 g were exposed to 0, 10, 20, 30, 40, 60, 80, 100, 150, and 200 mg\/l of CuO\u2010NPs (10 treatment with three replicates) for 96 hrs. After 24, 48, 72, and 96 hrs exposures, mortality rates recorded and gill samples were collected. Statistical analysis showed significant differences in carp survival between control and treatment groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); regression between fish mortality rate and NPs\u2010CuO concentration was also revealed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The LC<jats:sub>50<\/jats:sub> 96h of NPs\u2010CuO for common carp was estimated as 124.9 mg\/l in this study. Various tissue damages were observed in gill of treatments; such as, hypertrophy, hyperplasia, lamellar fusions, erythrocyte infiltration, epithelial lifting; also, there was significant correlation between intensity of tissue lesions and concentration of NPs\u2010CuO (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The findings of the present study demonstrate that sublethal concentration of NPs\u2010CuO can lead to serious tissue lesions. Whats more, concentrations above 30 ml\/l of NPs\u2010CuO can lead to some clinical signs; such as skin darkening and death with open mouth as well as definite fish death.<\/jats:p>","DOI":"10.1002\/jemt.23028","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T21:40:14Z","timestamp":1523396414000},"page":"724-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Histopathological lesions and toxicity in common carp (<i>Cyprinus carpio<\/i> L. 1758) induced by copper nanoparticles"],"prefix":"10.1002","volume":"81","author":[{"given":"Mohammad","family":"Forouhar Vajargah","sequence":"first","affiliation":[{"name":"Department of Fisheries, Faculty of Natural Resources University of Guilan Sowmehsara  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mohamadi Yalsuyi","sequence":"additional","affiliation":[{"name":"Department of Aquaculture, Faculty of Fisheries and Environment Gorgan University of Agricultural Sciences and Natural Resources Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliakbar","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Department of Aquatic production and Exploitation, Faculty of Fisheries and Environment Gorgan University of Agricultural Sciences and Natural Resources Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-2421","authenticated-orcid":false,"given":"Caterina","family":"Faggio","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2018.02.042"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-89132015050244"},{"key":"e_1_2_6_4_1","first-page":"369","article-title":"Effect of copper oxide nanoparticles to sheepshead minnow (Cyprinodon variegatus) at different salinities","volume":"9","author":"Ates M.","year":"2014","journal-title":"Digest Journal of Nanomaterials and Biostructures"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1079-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2017.12.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma5122850"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.10.003"},{"issue":"6","key":"e_1_2_6_9_1","first-page":"254","article-title":"Acute toxicity of Diazinon to the Caspian vimba, Vimba vimba persa (Cypriniformes: Cyprinidae)","volume":"1","author":"Chorehi M. 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