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However, the existing morphological researches of HAE mainly depend on the conventional CT, MRI, or ultrasound in hospitals, unfortunately confronting with the common limit of imaging resolution and sensitivity, especially for tiny or early HAE lesions. Now we presented a phase\u2010retrieval\u2010based synchrotron X\u2010ray phase computed tomography (PR\u2010XPCT) with striking contrast\u2010to\u2010noise ratio and high\u2010density resolution to visualize the HAE nondestructive 3D structures and quantitatively segment different pathological characteristics of HAE lesions without staining process at the micrometer scale. Our experimental results of the HAE rat models at early and developed pathological stages and albendazole liposome (L\u2010ABZ) therapeutic feeding models successfully exhibited the different HAE pathological 3D morphological and microstructural characteristics with excellent contrast and high resolution, demonstrating its availability and superiority. Moreover, we achieved the quantitative statistics and analysis of the pathological changes of HAE lesions at different stages and L\u2010ABZ therapeutic evaluation, helpful to understanding the development and drug treatment of HAE disease. The PR\u2010XPCT\u2010based quantitative segmentation and characterization has a great potential in detection and analysis of soft tissue pathological changes, such as different tumors.<\/jats:p>","DOI":"10.1002\/jemt.23114","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T17:56:10Z","timestamp":1537552570000},"page":"1173-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative characterization and diagnosis via hard X\u2010ray phase\u2010contrast microtomography"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-584X","authenticated-orcid":false,"given":"Huiqiang","family":"Liu","sequence":"first","affiliation":[{"name":"College of Medical Engineering and Technology Xinjiang Medical University  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