{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:31:08Z","timestamp":1787509868980,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific and Technological projects in Shaanxi Province","award":["2014K11-03-01-03"],"award-info":[{"award-number":["2014K11-03-01-03"]}]},{"name":"The Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University","award":["XJTU1AF-CRF-2015-007"],"award-info":[{"award-number":["XJTU1AF-CRF-2015-007"]}]},{"name":"First Affiliated Hospital of Xi'an Jiaotong University","award":["XJTU1AF-CRF-2015-007"],"award-info":[{"award-number":["XJTU1AF-CRF-2015-007"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We analysed lncRNA expression profiles in atrial samples from patients with rheumatic mitral valve disease (RMVD) to identify the potential differences in atrial fibrillation (AF)\u2010associated lncRNAs between RMVD patients with AF and sinus rhythm (SR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Masson's trichrome staining and scanning electron microscopy were performed to evaluate the tissue morphology. Western blotting was performed to detect the expression of fibrosis\u2010related proteins. Difference analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene co\u2010expression networks were also adopted to perform IncRNA expression profile analysis in atrial samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Masson's trichrome staining indicated higher contents of fat deposition and fibrous tissue in atrial samples from patients with AF than from patients with SR. Western blotting showed that fibrosis\u2010related proteins, including smad2, TGF\u03b21, MMP9, and TIMP1, were upregulated in atrial samples from patients with AF compared to those from patients with SR. lncRNA expression profiles showed different lncRNA expression levels between RMVD patients with AF and SR. Moreover, GO, KEGG and gene co\u2010expression networks showed consistent results and indicated that differentially expressed genes might contribute to the pathogenesis of AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results revealed the potential roles of IncRNAs in the development of AF in patients with RMVD, and lncRNAs may be responsible for morphological and physiological differences in atria between RMVD patients with AF and SR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jemt.23261","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:48:16Z","timestamp":1555030096000},"page":"1136-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification of atrial fibrillation\u2010associated lncRNAs in atria from patients with rheumatic mitral valve disease"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-2050","authenticated-orcid":false,"given":"Jine","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Cardiovascular Medicine the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Department of Xi'an Jiaotong University Electron Microscope Room  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Disease The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-0261","authenticated-orcid":false,"given":"Yang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1994.03510350050036","volume-title":"Independent risk factors for atrial fibrillation in a population\u2010based cohort: The Framingham heart study","author":"Benjamin E. 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