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A volume of 1.25\u2009\u03bcl of QD was injected into the left anterior camera of all rats. Similarly,1.25\u2009\u03bcl of ICG diluted at a ratio of one\u2010fourth with physiological saline solution was injected into the right anterior camera of all rats. The thickness of the skin in the mandibular area, connective tissue, and the depth of the mandibular lymph node (MLN) made image retrieval difficult. For QD, 302\u2009nm UV excitation and 605\u2009nm fluorescence peak emission were applied. The detection of QD and ICG used in this study in the MLNs is definitive evidence that aqueous humor (AH) follows a uveolymphatic pathway. Scanning electron microscope and the energy dispersive X\u2010ray analyzer spectrum were used to examine both the Schlemm's canal and the MLN. For the first time, the QD was detected in the cortex of MLN. The QCM analysis of both QD\u2010AH and ICG\u2010AH was used to determine whether there was any interaction between them. This comparative study shows the importance of experimental animal modeling in pharmacological studies regarding eye research and drugs. In a female rat, the signal was taken from the parotid lymph node with QD injections.<\/jats:p>","DOI":"10.1002\/jemt.23494","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T14:35:35Z","timestamp":1590244535000},"page":"1032-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Morphological analysis of aqueous humor drainage using <scp>QD<\/scp> nanoparticles and indocyanine green"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-8112","authenticated-orcid":false,"given":"\u0130smail Hakk\u0131","family":"Nur","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eerife","family":"Sa\u00e7mac\u0131","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Science Faculty Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130mdat","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Perez","sequence":"additional","affiliation":[{"name":"\u00c1rea de Anatom\u00eda, Facultad de Veterinaria Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Testereci","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0504"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04480"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068942"},{"issue":"1","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2460\/ajvr.1985.46.01.84","article-title":"Quantitation of uveoscleraloutflow in normotensive and glaucomatous beagles by 3H\u2010labeled dextran","volume":"46","author":"Barrie K. 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