{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:12:54Z","timestamp":1760634774204,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated changes in calcitonin cells (C\u2010cells) and parathyroid glands (PTG) induced by microcystin LR (MCLR) exposure to rats and evaluated ameliorative effects of jamun (<jats:italic>Syzygium cumini<\/jats:italic>) seed (JSE) and orange (<jats:italic>Citrus sinensis<\/jats:italic>) peel (OPE) extracts. Wistar rats were treated as\u2014Group A (control), Group B (MCLR), Group C (MCLR\u2009+\u2009JSE), Group D (MCLT\u2009+\u2009OPE), Group E (OPE) and Group F (JSE). Microcystin dose was (10 \u03bcg\/kg body wt\/day whereas OPE and JSE dose was 200\u2009mg\/kg body wt\/day. Thyroid and PTG were fixed on 15 and 30\u2009days following the treatment. C\u2010cells of treated rats for 15\u2009days with MCLR; MCLR\u2009+\u2009JSE and MCLR\u2009+\u2009OPE exhibit degranulation, mitochondrial swelling and prominent RER. In MCLR treated rats few cells completely lack secretory granules. After 30\u2009days MCLR treatment accumulation of secretory granules and degeneration were noticed in C\u2010cells. C\u2010cell nuclear volume (NV) of MCLR, MCLR\u2009+\u2009JSE and MCLT\u2009+\u2009OPE treated rats show an increase. In MCLR, MCLR\u2009+\u2009JSE and MCLR\u2009+\u2009OPE treated rats PTG exhibit hyperchromatic nuclei, nuclear elongation and increased NV after 15\u2009days. After 30\u2009days MCLR treatment nuclei of PTG become more hyperchromatic, more elongated, show degeneration of nuclei and increase in NV. NV is increased in Group C and Group D. PTG remain unaltered 30\u2009days following treatment with OPE and JSE. Microcystin LR provoke physiological effects on the blood calcium and alterations in C cells and PTG, which cause serious threat to organism. These changes can be protected by JSE and OPE.<\/jats:p>","DOI":"10.1002\/jemt.23615","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T07:19:10Z","timestamp":1604301550000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ameliorative effects of jamun seed and orange peel extracts on microcystin <scp>LR<\/scp> induced alterations in calcitonin cells and parathyroid gland of rats"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-5360","authenticated-orcid":false,"given":"Babita Deep","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Zoology DDU Gorakhpur University  Gorakhpur Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-2763","authenticated-orcid":false,"given":"Manish","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Chemistry Digvijai Nath P.G. College  Gorakhpur Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-9324","authenticated-orcid":false,"given":"Sunil Kumar","family":"Srivastav","sequence":"additional","affiliation":[{"name":"Department of Zoology DDU Gorakhpur University  Gorakhpur Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-9987","authenticated-orcid":false,"given":"Makoto","family":"Urata","sequence":"additional","affiliation":[{"name":"Institute of Noto SATOUMI Education Research  Noto\u2010cho Ishikawa Japan"},{"name":"Noto Marine Laboratory Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University  Noto\u2010cho Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-9910","authenticated-orcid":false,"given":"Nobuo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Noto Marine Laboratory Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University  Noto\u2010cho Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-0434","authenticated-orcid":false,"given":"Ajai Kumar","family":"Srivastav","sequence":"additional","affiliation":[{"name":"Department of Zoology DDU Gorakhpur University  Gorakhpur Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00231-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2305-0500.270104"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039890009603403"},{"key":"e_1_2_7_5_1","unstructured":"Birnbaum L. 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