{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:54:49Z","timestamp":1790801689862,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["96\u201014569"],"award-info":[{"award-number":["96\u201014569"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to assess the remineralization of enamel caries lesions using the self\u2010assembling peptide P<jats:sub>11<\/jats:sub>\u20104 associated with different materials. Artificial early enamel lesions were prepared on 154 primary teeth. The samples were randomly divided into eight groups: (1) control, (2) P<jats:sub>11<\/jats:sub>\u20104, (3) fluoridate toothpaste (FT), (4) P<jats:sub>11<\/jats:sub>\u20104\u2009+\u2009FT, (5) casein phosphopeptide\u2013amorphous calcium phosphate (CPP\u2013ACP), (6) P<jats:sub>11<\/jats:sub>\u20104\u2009+\u2009CPP\u2013ACP, (7) fluoridate bioactive glass toothpaste (BT), and (8) P<jats:sub>11<\/jats:sub>\u20104\u2009+\u2009BT. The surface enamel microhardness (EMH) and energy\u2010dispersive X\u2010ray spectroscopy (EDS) of the teeth were then measured at the baseline, after demineralization, and after 28\u2009days of remineralization. The enamel surfaces were assessed by field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM). The data were analyzed with one\u2010way analysis of variance (ANOVA) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). EMH after demineralization was significantly lower than the baseline value (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The interventions led to an enhanced percentage of EMH recovery (%REMH), which was higher in Groups 6 and 7. There was no significant difference between Groups 3 and 4. Groups 1 and 2 had the lowest %REMH. The mean calcium\/phosphate weight percentage ratio of P<jats:sub>11<\/jats:sub>\u20104 was significantly lower than the others (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The FESEM and AFM images revealed mineral deposition on the eroded enamel and reductions in surface roughness in Groups 5 and 7.<\/jats:p>","DOI":"10.1002\/jemt.23937","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T05:31:27Z","timestamp":1632288687000},"page":"630-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Remineralization effects of self\u2010assembling peptide <scp>P<sub>11<\/sub><\/scp>\u20104 associated with three materials on early enamel carious lesions: An in vitro study"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-5913","authenticated-orcid":false,"given":"Mahtab","family":"Memarpour","sequence":"first","affiliation":[{"name":"Oral and Dental Disease Research Center, Department of Pediatric Dentistry, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-3481","authenticated-orcid":false,"given":"Faranak","family":"Razmjouei","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, Department of Pediatric Dentistry, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azade","family":"Rafiee","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, Department of Pediatric Dentistry, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Vossoughi","sequence":"additional","affiliation":[{"name":"Oral and Dental Disease Research Center, Department of Dental Public Health, School of Dentistry Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/97311"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517730531"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11091636"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.01.043"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2013.741"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sca.21276"},{"key":"e_1_2_9_8_1","first-page":"5701638","article-title":"Dentine tubule occlusion by novel bioactive glass\u2010based toothpastes","volume":"4","author":"Cruz L. 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