{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:04:47Z","timestamp":1783044287445,"version":"3.54.6"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The adrenal glands are paired abdominal endocrine organs vital to the bird's health. The present research aimed to provide a comprehensive examination of the histological, ultrastructural, and immunohistochemical investigations of the adrenal gland in Japanese quail during the post hatching period. The current study was performed on 21 healthy Japanese quail chicks at different post hatching periods. Our results showed the adrenal gland is surrounded by a connective tissue capsule, which consists of dense collagen fibers containing large blood vessels, chromaffin cells, autonomic ganglia, fibroblasts, and migrating Schwann cells. The zonation of the adrenal gland is composed of a subcapsular layer, a peripheral zone, and a central zone, which gets more pronounced with age. At the ultrastructural level, the interrenal cells take the steroid\u2010secreting cells characters; they have varying amounts of lipid droplets and abundant mitochondria. Adrenal medullary chromaffin cells showed positive immunoreactivity to the NSE. With increasing age, the chromaffin tissue's Sox10 immunoreactivity increased. \u03b2\u2010catenin is expressed within the plasmalemma and the cytoplasm of the interrenal and chromaffin cells and its reactivity increased with age, especially in the chromaffin cells. Our results indicate the adrenal gland undergoes significant morphological changes during the postnatal life. Overall, the postnatal period is an important time for the development and maturation of the adrenal glands.<\/jats:p>","DOI":"10.1002\/jemt.24348","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T07:40:01Z","timestamp":1684482001000},"page":"1461-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Post\u2010hatching developmental changes in the adrenal gland of the Japanese quail (<i>Coturnix coturnix japonica<\/i>): Histological, immunohistochemical, and electron microscopic studies"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0343-3963","authenticated-orcid":false,"given":"Fatma M.","family":"Abdel\u2010maksoud","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saher","family":"Fadl","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abou\u2010Elmagd","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissues, Faculty of Veterinary Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelmohaimen M.M.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-006-0081-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.049"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.33762\/bvetr.2016.124294"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1431927622000666"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78192-7"},{"key":"e_1_2_10_7_1","article-title":"Light and electron microscopic studies on theinterrenal tissue of the adrenal gland in Japanese quail (Coturnix coturnixjaponica)","volume":"74","author":"Basha S. H.","year":"2014","journal-title":"The Indian Journal of Animal Sciences"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2019.tb00098.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001790303"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407160-5.00026-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.12.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2007.00821.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2004.00600.x"},{"key":"e_1_2_10_15_1","first-page":"227","article-title":"The mechanism of the differential staining reaction for adrenaline\u2010and noreadrenaline\u2010storing granules in tissues fixed in glutaraldehyde","volume":"100","author":"Coupland R.","year":"1966","journal-title":"Journal of Anatomy"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-017-2514-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.12.014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253281"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.23791"},{"key":"e_1_2_10_20_1","first-page":"195","volume-title":"Light and electron microscope studies of the adrenal glands of the Egyptian geese (Alopochen aegyptiacus)","author":"Elzoghby I. M.","year":"2010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63952-7"},{"key":"e_1_2_10_22_1","first-page":"70","article-title":"Morphological, histological, and histochemical studies on the adrenal gland of the Japanese quail (Coturnix japonica) during the post hatching period","volume":"13","author":"Fadl S.","year":"2023","journal-title":"Journal of Advanced Veterinary Research"},{"key":"e_1_2_10_23_1","article-title":"Post Hatch Development of Chromaffin Tissuein theAdrenal Gland of Kuttanad Ducks (Anas Platyrhynchos Domesticus)","volume":"3","author":"Lucy K.","year":"2014","journal-title":"International Journal of Innovative Researchand Development"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3753"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmicro\/dfy146"},{"key":"e_1_2_10_26_1","first-page":"1","article-title":"Avian adrenal medulla: Cytomorphology and function","volume":"45","author":"Ghosh A.","year":"2001","journal-title":"Acta Biologica Szegediensis"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090950404"},{"key":"e_1_2_10_28_1","first-page":"777","article-title":"On the rapid conversion of haematoxylin into haematein in staining reactions","volume":"3","author":"Harris, H. J. J. o. A. M. L. M.","year":"1900","journal-title":"Journal of Applied Microscopic Laboratory Methods"},{"key":"e_1_2_10_29_1","first-page":"28","article-title":"Smallgranule\u2010containing (SGC) cells in the hamster adrenal medulla","volume":"10","author":"Ho W.\u2010H.","year":"1994","journal-title":"Gaoxiong yi xue ke xue za zhi= The KaohsiungJournal of Medical Sciences"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.04.004"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.011038"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0039"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2020.403"},{"key":"e_1_2_10_34_1","first-page":"223","article-title":"Morphological aspects of chromaffin tissue: The differential fixation of adrenaline and noradrenaline","volume":"183","author":"Kobayashi S.","year":"1993","journal-title":"Journal of Anatomy"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.456"},{"key":"e_1_2_10_36_1","first-page":"348","article-title":"Post hatch development of chromaffin Tissuein the adrenal gland of Kuttanad ducks (Anas Platyrhynchos Domesticus)","volume":"3","author":"Lucy F. R. a. K. M.","year":"2014","journal-title":"International Journal of Innovative Research and Development"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91168-3"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233870"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.105.1.25"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2017.04.001"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1431927617012727"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67103-5"},{"key":"e_1_2_10_43_1","article-title":"Adrenal stem cell niches are located between adrenal and renal capsules","volume":"5","author":"Obinu E.","year":"2016","journal-title":"Journal of Pediatric and Neonatal Individualized Medicine"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.8.1237"},{"key":"e_1_2_10_45_1","volume-title":"Anatomy of the domestic animals and fowls","author":"Peng K.","year":"2005"},{"key":"e_1_2_10_46_1","first-page":"729","volume-title":"Via interstitial Cajal\u2010like cells (ICLC) to TELOCYTES","author":"Popescu L.","year":"2010"},{"key":"e_1_2_10_47_1","first-page":"102I","article-title":"Electron microscopical study of adrenal gland in Guinea fowl","volume":"45","author":"Prabhavathi M.","year":"2011","journal-title":"Indian Journal of Animal Research"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-08-0782"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_10_50_1","unstructured":"Roffi J.(1968).Influence des corticosurr\u00e9nales sur la synth\u00e8se d'adr\u00e9naline chez le foetus et le nouveau\u2010n\u00e9 de rat et de lapin."},{"key":"e_1_2_10_51_1","unstructured":"Salem H. F. Moustafa I. A. Balah A. M. Eidaroos H. &Bareedy M. H.(1989).Microscopic studies on the adrenal glands of domestic TurkeyM (Meleagris Jallopavo). 13th Scientific Conference of the Egyptian Society of Histology and Cytology."},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00223-X"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/276834a0"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(69)90033-1"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2008.11.003"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22445"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00223124"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.277756.116"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb08014.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2009.00981.x"},{"key":"e_1_2_10_61_1","first-page":"1","article-title":"Study on adrenal glands of Wanxi white geese","volume":"13","author":"Wang J.","year":"1999","journal-title":"Journal of Anhui Agricultural University"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-4-974"}],"container-title":["Microscopy Research and Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.24348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:09:29Z","timestamp":1760630969000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jemt.24348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jemt.24348"],"URL":"https:\/\/doi.org\/10.1002\/jemt.24348","archive":["Portico"],"relation":{},"ISSN":["1059-910X","1097-0029"],"issn-type":[{"value":"1059-910X","type":"print"},{"value":"1097-0029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"assertion":[{"value":"2023-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}