{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:45:33Z","timestamp":1790286333996,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The structure of photoreceptors (PR) and the arrangement of neurons in the retina of red\u2010tail shark were investigated using light and electron microscopy. The PR showed a mosaic arrangement and included double cones, single cones (SC), and single rods. Most cones occur as SC. The ratio between the number of cones and rods was 3:1.39 (\u00b10.29). The rods were tall that reached the pigmented epithelium. The outer plexiform layer (OPL) showed a complex synaptic connection between the horizontal and photoreceptor terminals that were surrounded by M\u00fcller cell processes. Electron microscopy showed that the OPL possessed both cone pedicles and rod spherules. Each rod spherule consisted of a single synaptic ribbon within the invaginating terminal endings of the horizontal cell (hc) processes. In contrast, the cone pedicles possessed many synaptic ribbons within their junctional complexes. The inner nuclear layer consisted of bipolar, amacrine, M\u00fcller cells, and hc. M\u00fcller cells possessed intermediate filaments and cell processes that can reach the outer limiting membrane and form connections with each other by desmosomes. The ganglion cells were large multipolar cells with a spherical nucleus and Nissl\u2019 bodies in their cytoplasm. The presence of different types of cones arranged in a mosaic pattern in the retina of this species favors the spatial resolution of visual objects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>This is the first study demonstrating the structure and arrangement of retinal neurons of red\u2010tail shark using light and electron microscopy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The current study showed the presence of different types of cones arranged in a mosaic pattern that may favor the spatial resolution of visual objects in this species.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The bipolar, amacrine, M\u00fcller, and horizontal cells could be demonstrated.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/jemt.24488","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T01:46:20Z","timestamp":1704764780000},"page":"1009-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Light and electron microscopic observations on retinal neurons of red\u2010tail shark (<i>Epalzeorhynchos bicolor<\/i> H. M. Smith, 1931)"],"prefix":"10.1002","volume":"87","author":[{"given":"Doaa M.","family":"Mokhtar","sequence":"first","affiliation":[{"name":"Department of Cell and Tissues, Faculty of Vet. Medicine Assiut University  Assiut Egypt"},{"name":"Department of Histology and Anatomy, School of veterinary medicine Badr University in Assiut  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-8114","authenticated-orcid":false,"given":"Alessio","family":"Alesci","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pergolizzi","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Zaccone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Polo Universitario dell'Annunziata University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01350031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2016.00078"},{"key":"e_1_2_10_4_1","volume-title":"Theory and practice of histological and histochemical techniques","author":"Bancroft J. 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