{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:35:01Z","timestamp":1770489301565,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Process"],"award-info":[{"award-number":["Process"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405914\/2021\u20100"],"award-info":[{"award-number":["405914\/2021\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Molar\u2010incisor hypomineralization (MIH) is a qualitative defect of dental enamel characterized by demarcated opacities present in permanent first molars and other teeth. It is considered a major clinical challenge in dentistry because it makes affected teeth more susceptible to fractures and dental caries. Its diagnosis is mainly clinical and there are few technological resources that allow for a more accurate diagnosis, especially with respect to the depth of the defect in the dental enamel. In this context, optical coherence tomography (OCT), which is routinely used in ophthalmology, can produce images of the depth of the dental enamel, making it a promising method. In this study, 33 teeth with different MIH severities were evaluated using OCT and microcomputed tomography (microCT). Semi\u2010quantitative methods of grayscale pattern analysis were used to compare images obtained from different severities of MIH with the mineral density obtained through microCT. MicroCT evaluation revealed that hypomineralized enamel had a significantly lower mineral density than intact enamel. However, this difference was not observed between the mild and severe MIH lesions. In the OCT evaluation, significant differences were observed between the intact and hypomineralized enamel, and the gray value comparison provided a method for quantitative differentiation between the two. This study suggests that OCT could be a useful adjunct to traditional diagnostic methods for MIH, offering a noninvasive approach to evaluate enamel defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research Highlights<\/jats:title><jats:p>Combining optical coherence tomography with grayscale digital analysis shows potential as a promising method for diagnosing molar\u2010incisor hypomineralization and assessing its level of severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jemt.24558","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:56:10Z","timestamp":1711446970000},"page":"1810-1821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optical coherence tomography and gray scale digital analysis as noninvasive techniques for evaluating molar\u2010incisor hypomineralization severity: A comparative study with microcomputed tomography"],"prefix":"10.1002","volume":"87","author":[{"given":"Maria Livia Rodrigues","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayla Natalia","family":"Ferezin","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Caroline","family":"Gomes","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente Silva","family":"Mattos","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-1790","authenticated-orcid":false,"given":"Jardel Francisco","family":"Mazzi\u2010Chaves","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7696-7600","authenticated-orcid":false,"given":"Manoel Dami\u00e3o","family":"Sousa\u2010Neto","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2900-5000","authenticated-orcid":false,"given":"Alexandra Mussolino","family":"de Queiroz","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-532X","authenticated-orcid":false,"given":"Francisco Wanderley Garcia","family":"de Paula\u2010Silva","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-0583","authenticated-orcid":false,"given":"Fabr\u00edcio Kitazono","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.3.036004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02955-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.05.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.08.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2007.00908.x"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"61","article-title":"Onset of molar incisor hypomineralization (MIH)","volume":"37","author":"Fagrell T. 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