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The nasal cavity is divided into three sections: the olfactory, respiratory, and vestibular areas. The surface epithelium lining the <jats:italic>regio vestibularis<\/jats:italic> is the first tissue in the nose to be directly affected by environmental antigens. Cetaceans have a significant amount of mucosa\u2010associated lymphoid tissue (MALT) located throughout their bodies. The lymphoid tissue found in the nasal mucosa is known as nose\u2010 or nasopharynx\u2010associated lymphoid tissue (NALT). NALT has not yet been studied in dolphins, but it has been identified and documented in humans and laboratory rodents. This study utilized toll\u2010like receptor 2 (TLR2), CD4, Langerin\/CD207, and inducible nitric oxide synthase to characterize, for the first time, immune cells in the mucosal <jats:italic>regio vestibularis<\/jats:italic> of the <jats:italic>S<\/jats:italic>. <jats:italic>coeruleoalba<\/jats:italic> nasal cavity using confocal microscopy immunofluorescence techniques. The findings revealed scattered immune cells immunoreactive to the tested antibodies, present in both the epithelial tissue lining the nasal cavity vestibulum and the underlying connective tissue. This study enhances our comprehension of the immune system of cetaceans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>This study provides new insights into NALT in <jats:italic>S<\/jats:italic>. <jats:italic>coeruleoalba<\/jats:italic>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This research deepens the knowledge of the skin of cetaceans.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/jemt.24592","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T09:13:55Z","timestamp":1714382035000},"page":"2103-2112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunohistochemistry of the nasal cavity\u2010associated lymphoid tissue in the dolphin (<i>Stenella coeruleoalba<\/i>, <scp>Meyen<\/scp> 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