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This study inspected the in\u00a0vivo anticoccidial efficacy of biosynthesized zinc oxide nanoparticles (Bio\u2010ZnNPs) from <jats:styled-content style=\"fixed-case\"><jats:italic>Coriandrum sativum<\/jats:italic><\/jats:styled-content> leaves in mice infected with <jats:italic>Eimeria papillata<\/jats:italic>. Bio\u2010ZnNPs were described using transmission electron microscopy (TEM), UV\u2013visible spectroscopy, and x\u2010ray diffraction (XRD). Five groups of mice were applied: a control group (uninfected), a Bio\u2010ZnNPs group (uninfected, receiving 50\u2009mg\/kg of Bio\u2010ZnNPs), an infection group (untreated, infected with 10<jats:sup>3<\/jats:sup> sporulated oocysts), an INF\u2009+\u2009Bio\u2010ZnNPs group (infected, treated with Bio\u2010ZnNPs, 50\u2009mg\/kg), and an INF\u2009+\u2009AC group (infected, treated with amprolium, 120\u2009mg\/kg). The treatments lasted for 5\u2009days. Bio\u2010ZnNPs were spherical, averaging 35.79\u2009\u00b1\u20097.47\u2009nm in diameter, with a peak absorption at 300.06\u2009nm and four diffraction peaks in the XRD spectrum. An increased excretion of oocysts was found in the INF mice group. Notable jejunal histopathological anomalies were marked by an elevation in total endogenous parasitic oocysts. There was also an increase in immunohistochemical (IHC) staining intensity of caspase\u20103 and enhanced antioxidant and apoptotic activity. Treatment with Bio\u2010ZnNPs reduced oocyst excretion, improved jejunal mucosal status, and significantly decreased total parasitic stages. Post\u2010treatment, caspase\u20103 levels and its IHC expression decreased, and jejunal GPX levels declined. Apoptotic gene expression showed a significant downregulation of caspase\u20103 and BAX, with BCL2 upregulation. Overall, Bio\u2010ZnNPs effectively suppressed <jats:styled-content style=\"fixed-case\"><jats:italic>E. papillata<\/jats:italic><\/jats:styled-content> proliferation in infected mice, suggesting their potential utility in the treatment of eimeriosis.<\/jats:p>","DOI":"10.1002\/jemt.24839","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:02:45Z","timestamp":1741726965000},"page":"2098-2108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Biosynthesized Zinc Oxide Nanoparticles Derived From <i>Coriandrum sativum<\/i>: A Novel Nanomedicine Strategy Against Coccidiosis"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-0014","authenticated-orcid":false,"given":"Shaimaa M.","family":"Kasem","sequence":"first","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Ismaeil","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"El\u2010Ashram","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rewaida","family":"Abdel\u2010Gaber","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science, King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-5800","authenticated-orcid":false,"given":"Mohamed A.","family":"Dkhil","sequence":"additional","affiliation":[{"name":"Zoology and Entomology Department, Faculty of Science Helwan University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabila M.","family":"Mira","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1139899"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/09731296241303542"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010016\u20105035\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.03.016"},{"key":"e_1_2_11_6_1","volume-title":"Arbeitsmethoden Der Makroskopischen und Mikroskopischen Anatomic Mit 283 Abbildungen Gustav","author":"Adam H.","year":"1964"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917\u2010023\u201003810\u20101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9100541"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765202020191107"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s162355"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1430960"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.21276\/sajp.2016.5.6.1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.9790\/3013\u2010067031742"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211059323"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2023.2186079"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12050750"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0891\u20105849(02)01115\u20102"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.31838\/srp.2020.12.315"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.07.017"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s79944"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010023\u201025383\u20100"},{"issue":"1","key":"e_1_2_11_22_1","first-page":"249","article-title":"Coriander Extract Mediated Green Synthesis of Zinc Oxide Nanoparticles and Their Structural, Optical and Antibacterial Properties","volume":"3","author":"Goutam S. 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