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Sluggish wound healing, infections, and hypertrophic scars still struggle in burn treatment. <jats:italic>Lycoperdon lividum<\/jats:italic>, a puffball mushroom enriched in polyphenols, has outstanding antioxidative and anti\u2010inflammatory properties. This study aimed to assess the benefits of <jats:italic>L. lividum<\/jats:italic> on second\u2010degree burn lesions in a rat model at 100\u00b0C. Seventy\u2010five male rats were haphazardly separated into five groups of 15 rats each: Control (without any skin burn induction\/treatment), skin burn (skin burn induction\/non\u2010treated), \u03b2\u2010sitosterol (treated with topical \u03b2\u2010sitosterol 0.25%), Vehicle (treated with Vaseline), and <jats:italic>L. lividum<\/jats:italic> (treated with topical <jats:italic>L. lividum watery<\/jats:italic> extract 10%). Rats were euthanized on Days 5, 10, and 20 of the experiment. <jats:italic>Lycoperdon lividum<\/jats:italic> extract was analyzed using HPLC techniques. Skin samples were collected for microscopical and histopathological examinations. Biomarkers involving IL\u20106, IL\u201010, TGF\u2010\u03b21, TNF\u2010\u03b1, and VEGF were analyzed in skin homogenates. The chromatogram revealed distinct peaks for bioactive compounds of <jats:italic>L. lividum<\/jats:italic>, including kaempferol, rutin, ferulic acid, caffeic acid, chlorogenic acid, quercetin, and gallic acid. <jats:italic>Lycoperdon lividum<\/jats:italic> greatly alleviated the burn lesions via improving wound contraction, correcting inflammation, and granulation aberrations while boosting fibrosis. The outcomes were validated by histopathological analyses. Further, <jats:italic>L. lividum<\/jats:italic> markedly improved the healing of burn wounds by regulating inflammatory cytokines (IL\u20106 and TNF\u2010\u03b1), anti\u2010inflammatory cytokines (IL\u201010 and TGF\u2010\u03b21), and angiogenic cytokines (VEGF) in skin tissues. <jats:italic>Lycoperdon lividum<\/jats:italic> has potential in healing burn wounds thanks to its outstanding antioxidant and anti\u2010inflammatory actions.<\/jats:p>","DOI":"10.1002\/jemt.24864","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T09:41:46Z","timestamp":1744278106000},"page":"2439-2466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Skin Healing Potential of Bioactive Components From <i>Lycoperdon lividum<\/i> Mushroom Versus \u03b2\u2010Sitosterol in Rat Model of Burn Wounds"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8257-9325","authenticated-orcid":false,"given":"Mohammed Radhi","family":"Thammer","sequence":"first","affiliation":[{"name":"College of Medicine, Department of Pharmacology Al\u2010Nahrain University  Baghdad Iraq"},{"name":"College of Pharmacy Al\u2010Manara University  Amarah Maysan Governorate Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-5622","authenticated-orcid":false,"given":"Hayder B.","family":"Sahib","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Department of Pharmacology and Toxicology Al\u2010Nahrain University  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1594-4883","authenticated-orcid":false,"given":"Hayder","family":"Ridha\u2010Salman","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Department of Pharmacology Al\u2010Mustaqbal University  Babylon Iraq Hilla"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.22092\/ari.2021.356202.1803"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml\u20102021\u20100255"},{"key":"e_1_2_12_4_1","first-page":"362","article-title":"The Attenuated Effects of Cimifugin on Imiquimod\u2010Induced Model of Psoriasis in Mice","volume":"42","author":"Abbas A.","year":"2023","journal-title":"Latin American Journal of Pharmacy"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.11594\/jtls.14.03.03"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735\u20105362.272565"},{"key":"e_1_2_12_7_1","first-page":"265","article-title":"Histological and Immunohistochemical Studies on the Role of Stem Cells on the Burned Skin of Adult Male Albino Rats","volume":"2","author":"Abd Allah F. 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