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However, manual annotation of multi\u2010stain pathology images incurs high labor costs. To address this challenge, we propose the deep dual\u2010channel coupling (DDC) method for multi\u2010stain pathology image matching. DDC utilizes virtual staining to establish two matching channels, bridging H&amp;E\u2010stained and IHC\u2010stained pathology images while effectively mitigating staining variations. Subsequently, each channel undergoes guided matching using deep descriptor representations of multi\u2010stain pathology images. Finally, a coupling strategy integrates the matching results from both channels, leveraging information from different channels to enhance accuracy and success rates. Experiment results demonstrate that DDC achieves a 93.81% success rate, surpassing the comparison method in estimating the gold standard based on 210 manual annotations. Compared to manual annotation errors, DDC improves accuracy by 45.24%, bringing it closer to the level of clinical manual annotation. Although DDC cannot replace pathologists in fully automated cancer classification, it serves as a limited aid for comprehensive assessments, demonstrating outstanding reliability in distinguishing malignant Hodgkin lymphoma and diagnosing ductal carcinoma in\u00a0situ of the breast. Therefore, DDC holds significant potential in matching pathology images and supporting clinical pathological diagnostic applications.<\/jats:p>","DOI":"10.1002\/jemt.24878","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:04:31Z","timestamp":1747631071000},"page":"2599-2611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Channel Coupling Approach Enhancing Multi\u2010Stain Pathology Image Matching for Enhancing Cancer Diagnostics"],"prefix":"10.1002","volume":"88","author":[{"given":"Xiaoxiao","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengping","family":"Long","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"},{"name":"Department of Pathology Peking University Cancer Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University Cancer Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University Cancer Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxuan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taobo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-9199","authenticated-orcid":false,"given":"Liye","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"},{"name":"School of Computer Science Hubei University of Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Technological Sciences Wuhan University  Wuhan China"},{"name":"Suzhou Institute of Wuhan University  Suzhou China"},{"name":"Shenzhen Institute of Wuhan University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278\u2010019\u201000182\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2019.101684"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1404640"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377\u2010023\u201001104\u20107"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.labinv.2025.104094"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.2986331"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compeleceng.2020.106767"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compind.2021.103551"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ins.2018.02.036"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2021.10.019"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681163.2015.1135299"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","unstructured":"Dai T. 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