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The early diagnosis increases the survival rates and also prevents the progression of endometrial cancer thereby, the novel Transfer Learning based Convolution Neural Network with Adam Gold Rush Optimization (TL\u2010CNN_AdGRO) is proposed to classify endometrial cancer using histopathological images. The histopathological image is fed to the preprocessing phase, which uses an Adaptive Weighted Mean Filter (AWMF). Next, the segmentation of endometrial cancer is utilized by the Directional Connectivity Network (DConn\u2010Net). Following segmentation, feature mining is carried out, which includes Local Boundary Summation Pattern (LBSP) and Local Gaber Binary Pattern Histogram Sequence Features (LGBPHS). Finally, the endometrial cancer classification is achieved using TL\u2010CNN by employing hyperparameters from the Xception model. Here TL\u2010CNN is trained by AdGRO algorithm, which is the combination of Adam Optimizer and Gold Rush Optimization.\u00a0Compared to existing models, the proposed model achieves superior performance with an accuracy of 91.876%, a True Positive Rate (TPR) of 93.987%, and a True Negative Rate (TNR) of 89.876% for <jats:italic>K<\/jats:italic>\u2010sample 8. The results confirm the effectiveness of TL\u2010CNN_AdGRO, also it demonstrates strong performance, ensures robustness, improves the early detection of endometrial cancer, and making it a promising approach for histopathological image analysis.<\/jats:p>","DOI":"10.1002\/jemt.70027","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:32:27Z","timestamp":1752075147000},"page":"3063-3082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transfer Learning With Adam Gold Rush Optimization for Endometrial Disease Classification Using Histopathological Image"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-7811","authenticated-orcid":false,"given":"Sudhagar","family":"Dhandapani","sequence":"first","affiliation":[{"name":"Department of Information Technology Jerusalem College of Engineering  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikumar","family":"Subburam","sequence":"additional","affiliation":[{"name":"Department of Computer Science &amp; Engineering Vel Tech Rangarajan Dr. Sagunthala R &amp; D Institute of Science and Technology  Avadi Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pretty Diana Cyril","family":"Cyriloose","sequence":"additional","affiliation":[{"name":"Department of Computing Technologies SRM Institute of Science and Technology  Kattankulathur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-7337","authenticated-orcid":false,"given":"Santhosh Kumar","family":"Balan","sequence":"additional","affiliation":[{"name":"INTL International University  Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42235-022-00316-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12612"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05467-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282577"},{"issue":"22","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40880-019-0368-6","article-title":"Current Cancer Situation in China: Good or Bad News From the 2018 Global Cancer Statistics?","volume":"39","author":"Feng R. 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