{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:06:13Z","timestamp":1789491973396,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. exp. orthop."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether intra\u2010articular injections of peripheral blood stem cells (PBSC) with hyaluronan (HA)\u2010based scaffold improve articular cartilage regeneration in chondral injuries caused by mixed\u2010femoroacetabular impingement syndrome (FAIS) over a period longer than 24 months post\u2010hip arthroscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective cohort study, patients with mixed\u2010FAIS and chondral injury \u2265 IIIB according to the International Cartilage Regeneration and Joint Preservation Society grade or III\/IV of Konan\/Haddad classification underwent intra\u2010articular injection of PBSC with an HA\u2010based scaffold and micro\u2010drillings during hip arthroscopy. The degree of chondral repair was measured at baseline and 5 years using the International Cartilage Repair Society morphologic score system (MSS) as the primary outcome. Pain was measured at baseline and 5 years using the Visual Analogue Scale for Pain (VAS Pain), and hip functionality was measured at baseline (presurgery), 6 months, 1 year, and 5 years using the Hip Outcome Score (HOS). The largest diameter of injury, median follow\u2010up, side effects, complications, and improvements were described.\n                      <jats:italic>T<\/jats:italic>\n                      \u2010test, ANOVA with multiple comparisons, and statistical power were estimated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From initially 34 cases, 25 patients were enrolled. The median follow\u2010up was 5.1\u2009\u00b1\u20090.3 years. One patient (4%) reported a few side effects with filgrastim administration. No infection, tumours, or synovitis was reported. The largest diameters in zones two, three, and four were 12.4\u2009\u00b1\u20093.1\u2009mm (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), 13.5\u2009\u00b1\u20092.8\u2009mm (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), and 11.4\u2009\u00b1\u20091.9\u2009mm (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), respectively. Ninety\u2010two percent (23\/25) of patients improved their outcomes. The MSS and HOS increased from 3.8\u2009\u00b1\u20091.1 to 9.6\u2009\u00b1\u20091.5 pts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and from 65.5\u2009\u00b1\u200913.0 to 93.9\u2009\u00b1\u20092.4 pts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively. The VAS\u2010Pain decreased from 5.3\u2009\u00b1\u20090.7 to 1.3\u2009\u00b1\u20090.6\u2009mm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The obtained a\n                      <jats:italic>posteriori<\/jats:italic>\n                      power\u2010size was 0.99.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intervention suggests a favourable impact on articular cartilage regeneration and clinical outcomes for hip chondral lesions in mixed\u2010FAIS injuries after a median follow\u2010up of 5.1\u2009\u00b1\u20090.3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV.<\/jats:p>\n                  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