{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:02:23Z","timestamp":1789844543871,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. exp. orthop."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This systematic review aimed to investigate the association between serum vitamin D levels and key outcomes following anterior cruciate ligament reconstruction (ACLR), including ACL injury risk, postoperative muscle recovery and post\u2010reconstruction functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive search across five databases (Cochrane Library, EMBASE, MEDLINE, Scopus and Web of Science) until July 2024. Studies were selected based on specific inclusion criteria, such as studies evaluating the relationship between vitamin D and injury risk, ACLR outcomes and muscle strength. Risk of bias was assessed using the MINORS tool, and results were synthesized narratively due to study heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five studies with 656,243 participants met the inclusion criteria. Most studies reported that low vitamin D levels were associated with a significantly increased risk of ACL injuries and poorer postoperative muscle strength recovery. However, evidence regarding bone health and functional outcomes was inconsistent. No meta\u2010analysis was conducted due to the variability of study designs and outcomes, but qualitative synthesis indicated a potential protective role of vitamin D in ACL recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin D deficiency appears to increase the risk of ACL injury and impede muscle recovery post\u2010surgery. However, limitations include a high risk of bias and inconsistent evidence on functional outcomes, underscoring the need for further research. The review was registered in PROSPERO (ID: CRD42024584483).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III, systematic review.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jeo2.70224","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T09:22:15Z","timestamp":1743585735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of vitamin D on anterior cruciate ligament injury rates and post\u2010reconstruction function\u2014A systematic review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8545-8330","authenticated-orcid":false,"given":"Andrea","family":"Pasquini","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology \u201cPius Brinzeu\u201d Emergency Clinical County Hospital Timisoara Romania"},{"name":"Center for Modeling Biological Systems and Data Analysis, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Prejbeanu","sequence":"additional","affiliation":[{"name":"Department XV\u2010Discipline of Orthopedics\u2010Traumatology \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-6866","authenticated-orcid":false,"given":"Octav","family":"Russu","sequence":"additional","affiliation":[{"name":"UMFST G.E. 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Mures T\u00e2rgu Mure\u0219 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-792X","authenticated-orcid":false,"given":"Riccardo","family":"D'Ambrosi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi Milan Italy"},{"name":"Dipartimento di Scienze Biomediche per la Salute Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-5584","authenticated-orcid":false,"given":"Cosmin Ioan","family":"Faur","sequence":"additional","affiliation":[{"name":"Department XV\u2010Discipline of Orthopedics\u2010Traumatology \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-2932","authenticated-orcid":false,"given":"Giulio Maria","family":"Marcheggiani 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