{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:24:27Z","timestamp":1793305467989,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. exp. orthop."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Meniscal extrusion alters joint biomechanics and accelerates cartilage degeneration, contributing to the progression of knee osteoarthritis (OA). Meniscal centralization techniques aim to reposition the meniscus, addressing extrusion and restoring load distribution. This systematic review aims to evaluate meniscal centralization's clinical and radiological outcomes, hypothesizing its efficacy in treating symptomatic meniscal extrusion with minimal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This review followed Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines and was registered with PROSPERO (CRD42023484353). Literature searches were conducted in PubMed, Science Direct and Scopus. Studies reporting clinical and\/or radiological outcomes of meniscal centralization with \u226524 months of follow\u2010up were included. Data on demographics, surgical techniques, patient\u2010reported outcome measures (PROMs), imaging findings and complications were extracted. Methodological quality was assessed using the ROBINS\u2010I tool, and heterogeneity was evaluated via the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four studies (113 patients, mean follow\u2010up: 24\u201335 months) met inclusion criteria. Arthroscopic meniscal centralization with suture anchors significantly improved PROMs, including International Knee Documentation Committee (IKDC), Lysholm and Knee Injury and Osteoarthritis Outcome Score (KOOS) scores, demonstrating symptom relief and functional recovery. Lysholm scores improved from 46.0 to 96.5, KOOS pain from 47.4 to 88.9, and IKDC from 51.8 to 75.8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for all). Imaging showed reduced meniscal extrusion and improved joint space width. Complications were minimal, though one study reported a 26.9% failure rate due to incomplete healing and OA progression. Rehabilitation protocols allowed return to full activity within 4\u20136 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Meniscal centralization effectively reduces extrusion, improves clinical outcomes, and restores knee function with minimal complications. However, further long\u2010term and comparative studies are needed to validate these findings and refine surgical indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jeo2.70308","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T15:28:36Z","timestamp":1750001316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Meniscal centralization significantly improve clinical outcomes and reduce meniscal extrusion with minimal complications: A systematic review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-8139","authenticated-orcid":false,"given":"Alessandro","family":"Carrozzo","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi \u201cLink Campus University\u201d, Dipartimento di Scienze della Vita, della Salute e delle Professioni Sanitarie Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-1869","authenticated-orcid":false,"given":"Francesco","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.) University of Palermo Palermo Italy"},{"name":"Department of Orthopaedics and Traumatology G.F. Ingrassia Hospital Unit (ASP 6) Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Ramazzini","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Casa di Cura Solatrix Rovereto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6386-2933","authenticated-orcid":false,"given":"Fortunato","family":"Giustra","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Ospedale San Giovanni Bosco di Torino \u2013 ASL Citt\u00e0 di Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-361X","authenticated-orcid":false,"given":"Virginia","family":"Masoni","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology University of Turin, CTO Turin 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