{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:12:39Z","timestamp":1791839559362,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. exp. orthop."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Implant loosening is a common cause of failure in total knee arthroplasty, and for appropriate treatment, the correct diagnosis is of vital importance. Detection is challenging as radiographs only reveal obvious cases, computed tomography (CT) scans are hindered by metal artifacts, and bone scintigraphy lacks specificity, while all methods are time\u2010consuming and\/or involve radiation exposure. This proof\u2010of\u2010concept study aimed to develop a deep learning (DL) tool to detect implant loosening using a set of two\u2010dimensional (2D) radiographs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 307 radiograph sets (anteroposterior and lateral) were collected, including 159 loose and 148 fixed primary knee implants (confirmed intraoperatively during revision surgery). Images were square\u2010cropped, centred on the implant, horizontally flipped for left knees, resized to 512\u2009\u00d7\u2009512 pixels and standardized for grayscale. A dual InceptionV3 DL algorithm was trained using fivefold cross\u2010validation. Performance was assessed using sensitivity, specificity, accuracy and receiver operating characteristic curves, with corresponding area under the curve (AUC) and compared to routine radiological reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean\u2009\u00b1\u2009standard deviation (SD) sensitivity, specificity and accuracy over the fivefolds were 71.7%\u2009\u00b1\u200910.7%, 87.0%\u2009\u00b1\u200914.2% and 79.2%\u2009\u00b1\u20094.0%, respectively. The overall AUC was 0.81, confidence interval (CI): [0.77\u20130.85]. The radiological report predictions reached a sensitivity of 51.3%, specificity of 99.2% and accuracy of 73.2%. The algorithm predicted significantly more cases correctly compared to standard radiological evaluations by a musculoskeletal specialized radiologist (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This proof\u2010of\u2010concept study demonstrated the feasibility of training a deep\u2010learning algorithm using 2D radiographs to detect implant loosening. Notably, the algorithm outperformed routine radiological evaluations, highlighting its potential to enhance the detection of loosening. These results are promising, considering the limited dataset. This tool could be valuable for patients experiencing issues after knee replacement surgery, helping to rule out implant loosening while reducing analysis time, radiation exposure and healthcare costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jeo2.70611","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:08:11Z","timestamp":1768810091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deep learning applied to standard radiographs improves detection of implant loosening in total knee arthroplasty: A proof\u2010of\u2010concept study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-9425","authenticated-orcid":false,"given":"Kelly","family":"Mills","sequence":"first","affiliation":[{"name":"Research Department Sint Maartenskliniek Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-0622","authenticated-orcid":false,"given":"Guido A.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, 3D Lab Radboud UMC Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7625-4259","authenticated-orcid":false,"given":"Simon N.","family":"van Laarhoven","sequence":"additional","affiliation":[{"name":"Research Department Sint Maartenskliniek Nijmegen the Netherlands"},{"name":"Orthopaedics Department Sint Maartenskliniek Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-4733","authenticated-orcid":false,"given":"Thomas J. J.","family":"Maal","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, 3D Lab Radboud UMC Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-8907","authenticated-orcid":false,"given":"Petra J. C.","family":"Heesterbeek","sequence":"additional","affiliation":[{"name":"Research Department Sint Maartenskliniek Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Achakri H Ben\u2010Shlomo Y Blom A Boulton C Bridgens J Brittain R et al. The National Joint Registry 20th Annual Report 2023. London: National Joint Registry; 2023."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-2024-2911"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-023-07483-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42836-022-00119-6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.04.051"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/frobt.2024.1444763"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","unstructured":"Goharian A Golkar E. Chapter one\u2014general concepts of interactions of bone with orthopedic implants and possible failures. In: Interactions of Bone with Orthopedic Implants and Possible Failures. Oxford (UK): Academic Press; 2022. p. 1\u201331.","DOI":"10.1016\/B978-0-323-95410-5.00002-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2010.04.026"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2016.034"},{"key":"e_1_2_12_11_1","first-page":"123","article-title":"Fracture detection in x\u2010rays using custom CNN and transfer learning models","volume":"12","author":"Hassan A","year":"2025","journal-title":"J Med Imaging AI"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-36"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1302\/2633-1462.36.BJO-2022-0043.R1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-06154-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85454-5"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.07.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02295996"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-1977-y"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006359"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B6.BJJ-2019-1577.R1"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/ryai.240300"}],"container-title":["Journal of Experimental Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jeo2.70611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jeo2.70611","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jeo2.70611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:30:05Z","timestamp":1775917805000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/jeo2.70611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jeo2.70611"],"URL":"https:\/\/doi.org\/10.1002\/jeo2.70611","archive":["Portico"],"relation":{},"ISSN":["2197-1153","2197-1153"],"issn-type":[{"value":"2197-1153","type":"print"},{"value":"2197-1153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70611"}}