{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:03:09Z","timestamp":1775919789923,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["esskajournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. exp. orthop."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the treatment and preventive effects, as well as the safety, of dual\u2010antibiotic bone cement (DABC; gentamicin\u2009+\u2009vancomycin) in revision total knee arthroplasty (RTKA) in high\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included patients who underwent RTKA for septic or aseptic indications with intraoperative application of DABC (Copal G\u2009+\u2009V, Heraeus\u2010Medical GmbH) at our centre between December 2015 and December 2022. Patients were followed for a minimum of 2 years. Postoperative infection rates were documented, and preoperative patient risk was calculated using the periprosthetic joint infection (PJI) risk calculator. Microbiological profiles and antibiotic resistance patterns of postoperative infections were analysed, and all complications were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 85 patients were included. The overall postoperative infection rate after DABC use was 17.6% (15\/85), 95% confidence interval (CI) [11.0%, 27.1%], while the mean preoperative PJI risk percentage was 54.19\u2009\u00b1\u200916.58%. When stratified by revision indication, infection rates were 21.2% (14\/66), 95% CI [13.1%, 32.5%] in septic revisions and 5.3% (1\/19), 95% CI [0.9%, 24.6%] in aseptic revisions, with corresponding preoperative PJI risk values of 54.34\u2009\u00b1\u200916.95% and 53.65\u2009\u00b1\u200915.62%. Among the 15 patients who developed postoperative infections, the most common organisms were\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) and\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095). Kidney complications occurred in 5.9% (5\/85), 95% CI [0.8%, 11.0%], and wound complications in 21.2% (18\/85), 95% CI [12.3%, 30.0%]. Implant removal or component exchange was required in 7.1% (6\/85), 95% CI [1.5%, 12.6%].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DABC (G\u2009+\u2009V) demonstrated favourable infection control in septic RTKA and effective infection prevention in aseptic RTKA, with a low complication rate and good overall safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jeo2.70638","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:25:41Z","timestamp":1769534741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual\u2010antibiotic bone cement (gentamicin\u2009+\u2009vancomycin) in preventing and treating infections during revision knee arthroplasty in high\u2010risk patients"],"prefix":"10.1002","volume":"13","author":[{"given":"Shengdong","family":"Yang","sequence":"first","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"},{"name":"IFSTTAR, LBMC UMR_T9406, Claude Bernard Lyon 1 University University of Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Cance","sequence":"additional","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Batailler","sequence":"additional","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"},{"name":"IFSTTAR, LBMC UMR_T9406, Claude Bernard Lyon 1 University University of Lyon Lyon France"},{"name":"Centre interr\u00e9gional de R\u00e9f\u00e9rence pour la prise en charge des Infections Ost\u00e9o\u2010Articulaires complexes (CRIOAc Lyon), Hospices Civils de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Ferry","sequence":"additional","affiliation":[{"name":"Centre interr\u00e9gional de R\u00e9f\u00e9rence pour la prise en charge des Infections Ost\u00e9o\u2010Articulaires complexes (CRIOAc Lyon), Hospices Civils de Lyon Lyon France"},{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital de la Croix\u2010Rousse, Hospices Civils de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Longlune","sequence":"additional","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1586-2542","authenticated-orcid":false,"given":"Luca","family":"Andriollo","sequence":"additional","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"},{"name":"Ortopedia e Traumatologia, Fondazione Poliambulanza Istituto Ospedaliero Brescia Italy"},{"name":"Artificial Intelligence Center Alma Mater Europaea University Vienna Austria"},{"name":"Ortopedia e Traumatologia Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Vermue","sequence":"additional","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"},{"name":"Department of Orthopedic Surgery and Traumatology Ghent University Hospital Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Lustig","sequence":"additional","affiliation":[{"name":"Orthopaedics Surgery and Sports Medicine Department IFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon Lyon North University Hospital Lyon France"},{"name":"IFSTTAR, LBMC UMR_T9406, Claude Bernard Lyon 1 University University of Lyon Lyon France"},{"name":"Centre interr\u00e9gional de R\u00e9f\u00e9rence pour la prise en charge des Infections Ost\u00e9o\u2010Articulaires complexes (CRIOAc Lyon), Hospices Civils de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2309499019839616"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24892"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13113092"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-5230-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2025.07.019"},{"issue":"9","key":"e_1_2_12_7_1","first-page":"1368","article-title":"A low rate of periprosthetic infections after aseptic knee prosthesis revision using dual\u2010antibiotic\u2010impregnated bone cement","volume":"12","author":"Blersch BP","year":"2023","journal-title":"Antibiot Basel Switz"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.04.014"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2024.05.030"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3342-7"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.07.043"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-4062-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.02.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-0391.R1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-024-05328-z"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04055-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeo2.70246"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081830"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeo2.70263"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.101B11.BJJ-2019-0196.R1"},{"issue":"2","key":"e_1_2_12_21_1","first-page":"328","article-title":"Research into biocompatibility and cytotoxicity of daptomycin, gentamicin, vancomycin and teicoplanin antibiotics at common doses added to bone cement","volume":"31","author":"K\u0131l\u0131n\u00e7 S","year":"2020","journal-title":"Jt Dis Relat Surg"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"328","article-title":"Research into biocompatibility and cytotoxicity of daptomycin, gentamicin, vancomycin and teicoplanin antibiotics at common doses added to bone cement","volume":"31","author":"K\u0131l\u0131n\u00e7 S","year":"2020","journal-title":"Jt Dis Relat Surg"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2023.02.011"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B6.BJJ-2019-1639.R1"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.4055\/cios22126"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.102B8.BJJ-2020-0120.R1"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.12898"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1243290"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijotn.2023.101048"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B11.33135"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.02.078"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeo2.70271"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2023.11.064"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12092082"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.02.030"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24616"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04689-5"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.01617"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.01.019"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.00874"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01435"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2012.01.027"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.811.BJR-2019-0339.R3"}],"container-title":["Journal of Experimental Orthopaedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jeo2.70638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jeo2.70638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jeo2.70638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:29:17Z","timestamp":1775917757000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1002\/jeo2.70638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jeo2.70638"],"URL":"https:\/\/doi.org\/10.1002\/jeo2.70638","archive":["Portico"],"relation":{},"ISSN":["2197-1153","2197-1153"],"issn-type":[{"value":"2197-1153","type":"print"},{"value":"2197-1153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70638"}}