{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:23:17Z","timestamp":1787653397936,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsess.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Env Quality"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pharmaceuticals serve as indispensable allies in human and veterinary medication. Acetaminophen (APAP) is extensively consumed as an analgesic and antipyretic medication. The indiscriminate usage of APAP has led to widespread consequences, transforming it into a formidable contaminant of emerging concern, posing severe and underestimated threats. Therefore, to eliminate APAP from the environment, the development of sustainable and efficient methods is compelling. In the present study,\n                    <jats:italic>Paracoccus<\/jats:italic>\n                    sp. APAP_BH8 was utilized for the biodegradation of APAP in a laboratory\u2010scale bioreactor packed with wood charcoal. The response surface methodology was employed for the optimization of distinct degradation parameters, revealing pH of 7.0, inoculum size of 0.3, co\u2010substrate concentration of 15\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and APAP concentration of 350\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    as most favorable. The bioreactor was intended for the removal of APAP at higher concentrations from wastewater. The bioreactor exhibited 90.58% degradation in batch mode studies, and the kinetic parameters\n                    <jats:italic>\n                      K\n                      <jats:sub>s<\/jats:sub>\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    , and\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \/\n                    <jats:italic>\n                      K\n                      <jats:sub>s<\/jats:sub>\n                    <\/jats:italic>\n                    were 322.58\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 53.52\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    day\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and 0.1659 day\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively. For the degradation in continuous mode, the bioreactor was operated at different flow rates and APAP concentrations. The removal efficiency observed in the range of 48.08%\u201389.35%, and the maximum elimination capacity was 721.19\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    h\n                    <jats:sup>\u22121<\/jats:sup>\n                    at an inlet concentration of 450\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Overall, the findings highlighted that\n                    <jats:italic>Paracoccus<\/jats:italic>\n                    sp. APAP_BH8 is a reliable, promising, and sustainable candidate for bioremediation of APAP and similar contaminants from pharmaceutical wastewater within wood charcoal packed\u2010bed bioreactor.\n                  <\/jats:p>","DOI":"10.1002\/jeq2.70232","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:59:36Z","timestamp":1785830376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Packed\u2010bed bioreactor\u2010based evaluation of\n                    <i>Paracoccus<\/i>\n                    sp. APAP_BH8 potential for acetaminophen biodegradation"],"prefix":"10.1002","volume":"55","author":[{"given":"Bhavana","family":"Pandey","sequence":"first","affiliation":[{"name":"Molecular Ecology Laboratory, Department of Botany, Institute of Science Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-6285","authenticated-orcid":false,"given":"Suresh Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Molecular Ecology Laboratory, Department of Botany, Institute of Science Banaras Hindu University  Varanasi 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