{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:42:23Z","timestamp":1793220143752,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti\u2010inflammatory effects. MSC\u2010EVs may serve as promising cell\u2010based therapeutics for the inner ear to attenuate inflammation\u2010based side effects from cochlear implantation which represents an unmet clinical need. In an individual treatment performed on a \u2018named patient basis\u2019, we intraoperatively applied allogeneic umbilical cord\u2010derived MSC\u2010EVs (UC\u2010MSC\u2010EVs) produced according to good manufacturing practice. A 55\u2010year\u2010old patient suffering from Meni\u00e8re's disease was treated with intracochlear delivery of EVs prior to the insertion of a cochlear implant. This first\u2010in\u2010human use of UC\u2010MSC\u2010EVs demonstrates the feasibility of this novel adjuvant therapeutic approach. The safety and efficacy of intracochlear EV\u2010application to attenuate side effects of cochlea implants have to be determined in controlled clinical trials.<\/jats:p>","DOI":"10.1002\/jev2.12094","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T23:42:44Z","timestamp":1622850164000},"source":"Crossref","is-referenced-by-count":96,"title":["First\u2010in\u2010human intracochlear application of human stromal cell\u2010derived extracellular vesicles"],"prefix":"10.1002","volume":"10","author":[{"given":"Athanasia","family":"Warnecke","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Prenzler","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Harre","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"K\u00f6hl","sequence":"additional","affiliation":[{"name":"Institute for Cellular Therapeutics Hannover and Institute of Clinical Immunology Hannover Medical School University of Leipzig as well as Fraunhofer Institute for Cell Therapy and Immunology (IZI)  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lenarz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Laner\u2010Plamberger","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine University Hospital Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU)  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Wietzorrek","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Pharmacology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinrich","family":"Staecker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Lassacher","sequence":"additional","affiliation":[{"name":"GMP Unit Spinal Cord Injury &amp; Tissue Regeneration Centre Salzburg (SCI\u2010TReCS) Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"Research Program Nanovesicular Therapeutics Paracelsus Medical University (PMU)  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hollerweger","sequence":"additional","affiliation":[{"name":"GMP Unit Spinal Cord Injury &amp; Tissue Regeneration Centre Salzburg (SCI\u2010TReCS) Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"Research Program Nanovesicular Therapeutics Paracelsus Medical University (PMU)  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Gimona","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine University Hospital Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"GMP Unit Spinal Cord Injury &amp; Tissue Regeneration Centre Salzburg (SCI\u2010TReCS) Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"Research Program Nanovesicular Therapeutics Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"Research and Transfer Centre for Extracellular Vesicle Theralytic Technologies  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine University Hospital Salzburger Landeskliniken GesmbH (SALK) and Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"GMP Unit Spinal Cord Injury &amp; Tissue Regeneration Centre Salzburg (SCI\u2010TReCS) Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"Research and Transfer Centre for Extracellular Vesicle Theralytic Technologies  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"issue":"3","key":"e_1_2_1_7_2_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2471\/BLT.18.209767","article-title":"Global hearing health: future directions","volume":"96","author":"Chadha S.","year":"2018","journal-title":"Bull World Health Organization"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13079298"},{"issue":"303","key":"e_1_2_1_7_4_1","first-page":"1","article-title":"Spiral ganglion cells and macrophages initiate neuro\u2010inflammation and scarring following cochlear implantation","volume":"9","author":"Bas E.","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0274"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070798"},{"key":"e_1_2_1_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1904407"},{"key":"e_1_2_1_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000753"},{"issue":"3","key":"e_1_2_1_7_9_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000445099","article-title":"Dexamethasone is one of the factors minimizing the inner ear damage from electrode insertion in cochlear implantation","volume":"21","author":"Cho H. S.","year":"2016","journal-title":"Audiology & Neuro\u2010otology"},{"key":"e_1_2_1_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8111867"},{"key":"e_1_2_1_7_11_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0078"},{"key":"e_1_2_1_7_12_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fphar.2014.00287","article-title":"Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss","volume":"5","author":"Fujioka M.","year":"2014","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_1_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061190"},{"key":"e_1_2_1_7_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2331216519833567","article-title":"Monitoring of the inner ear function during and after cochlear implant insertion using electrocochleography","volume":"23","author":"Haumann S.","year":"2019","journal-title":"Trends in Hearing"},{"key":"e_1_2_1_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01589.x"},{"issue":"2","key":"e_1_2_1_7_16_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.heares.2017.02.012","article-title":"The pattern and degree of capsular fibrous sheaths surrounding cochlear electrode arrays","volume":"348","author":"Ishai R.","year":"2017","journal-title":"Hearing Research"},{"key":"e_1_2_1_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000754"},{"key":"e_1_2_1_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.12.003"},{"key":"e_1_2_1_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047559"},{"key":"e_1_2_1_7_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17850"},{"issue":"1","key":"e_1_2_1_7_21_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12967-015-0717-4","article-title":"Mechanical fibrinogen\u2010depletion supports heparin\u2010free mesenchymal stem cell propagation in human platelet lysate","volume":"13","author":"Laner\u2010Plamberger S.","year":"2015","journal-title":"Journal of Translational Medicine"},{"key":"e_1_2_1_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(96)00115-3"},{"key":"e_1_2_1_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-815-3_10"},{"issue":"34","key":"e_1_2_1_7_24_1","first-page":"2663","article-title":"Umbilical cord\u2010derived mesenchymal stem cells retain immunomodulatory and anti\u2010oxidative activities after neural induction","volume":"7","author":"Li J.","year":"2012","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_1_7_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-150549"},{"issue":"0","key":"e_1_2_1_7_26_1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.12688\/f1000research.14417.1","article-title":"Towards personalized medicine in M\u00e9ni\u00e8re's disease","volume":"7","author":"Lopez\u2010Escamez J. A.","year":"2018","journal-title":"F1000Research"},{"issue":"7","key":"e_1_2_1_7_27_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-02803-4","article-title":"DNA from extracellular vesicles and particles","volume":"11","author":"Malkin E. Z.","year":"2020","journal-title":"Cell Death & Disease"},{"key":"e_1_2_1_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2015.07.003"},{"key":"e_1_2_1_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/108471380400800203"},{"key":"e_1_2_1_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517735844"},{"key":"e_1_2_1_7_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14992020802600808"},{"key":"e_1_2_1_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.02.014"},{"key":"e_1_2_1_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071413"},{"key":"e_1_2_1_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2017.01.001"},{"key":"e_1_2_1_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2575"},{"key":"e_1_2_1_7_36_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s13346-018-0539-z","article-title":"Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study","author":"Prenzler N. K.","year":"2018","journal-title":"Drug Delivery and Translational Research"},{"key":"e_1_2_1_7_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2015.08.018","article-title":"Delayed loss of hearing after hearing preservation cochlear implantation: human temporal bone pathology and implications for etiology","author":"Quesnel A.","year":"2016","journal-title":"Hearing Research"},{"key":"e_1_2_1_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22142"},{"key":"e_1_2_1_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2018.12.006"},{"key":"e_1_2_1_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01225"},{"key":"e_1_2_1_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000540"},{"key":"e_1_2_1_7_42_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.906210"},{"key":"e_1_2_1_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000847"},{"key":"e_1_2_1_7_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_2_1_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2008.02.002"},{"key":"e_1_2_1_7_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000829"},{"issue":"8","key":"e_1_2_1_7_47_1","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.262","article-title":"Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo","volume":"10","author":"Warnecke A.","year":"2020","journal-title":"Clinical and Translational Medicine"},{"key":"e_1_2_1_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.06.005"},{"key":"e_1_2_1_7_49_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066"},{"key":"e_1_2_1_7_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-106"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.12094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jev2.12094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.12094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:03:33Z","timestamp":1760630613000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.12094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/jev2.12094"],"URL":"https:\/\/doi.org\/10.1002\/jev2.12094","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"article-number":"e12094"}}