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Here we provide a robust set of data regarding the structural and compositional aspects of EVs isolated from the fungal pathogenic species\n                    <jats:italic>Cryptococcus neoformans, C. deneoformans<\/jats:italic>\n                    and\n                    <jats:italic>C. deuterogattii<\/jats:italic>\n                    . Using cutting\u2010edge methodological approaches including cryogenic electron microscopy and cryogenic electron tomography, proteomics, and flow cytometry, we revisited cryptococcal EV features and suggest a new EV structural model, in which the vesicular lipid bilayer is covered by mannoprotein\u2010based fibrillar decoration, bearing the capsule polysaccharide as its outer layer. About 10% of the EV population is devoid of fibrillar decoration, adding another aspect to EV diversity. By analysing EV protein cargo from the three species, we characterized the typical\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    EV proteome. It contains several membrane\u2010bound protein families, including some Tsh proteins bearing a SUR7\/PalI motif. The presence of known protective antigens on the surface of\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    EVs, resembling the morphology of encapsulated virus structures, suggested their potential as a vaccine. Indeed, mice immunized with EVs obtained from an acapsular\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    mutant strain rendered a strong antibody response in mice and significantly prolonged their survival upon\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1002\/jev2.12129","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T12:38:06Z","timestamp":1627907886000},"source":"Crossref","is-referenced-by-count":118,"title":["<i>Cryptococcus<\/i>\n                    extracellular vesicles properties and their use as vaccine platforms"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5538-6471","authenticated-orcid":false,"given":"Juliana","family":"Rizzo","sequence":"first","affiliation":[{"name":"Unit\u00e9 Biologie des ARN des Pathog\u00e8nes Fongiques D\u00e9partement de Mycologie, Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-1774","authenticated-orcid":false,"given":"Sarah Sze Wah","family":"Wong","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mycologie Mol\u00e9culaire, CNRS UMR2000 D\u00e9partement de Mycologie, Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2922-3625","authenticated-orcid":false,"given":"Anastasia D.","family":"Gazi","sequence":"additional","affiliation":[{"name":"Ultrastructural Bio\u2010Imaging, UTechS UBI, CNRS UMR 3528 D\u00e9partement de Biologie cellulaire et infection, Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Moyrand","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Biologie des ARN des Pathog\u00e8nes Fongiques D\u00e9partement de Mycologie, Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-7021","authenticated-orcid":false,"given":"Thibault","family":"Chaze","sequence":"additional","affiliation":[{"name":"Plateforme Prot\u00e9omique, Unit\u00e9 de Spectrom\u00e9trie de Masse pour la Biologie (MSBio), CNRS UMR 2000 Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3886-4256","authenticated-orcid":false,"given":"Pierre\u2010Henri","family":"Commere","sequence":"additional","affiliation":[{"name":"Cytometry and Biomarkers Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-3597","authenticated-orcid":false,"given":"Sophie","family":"Novault","sequence":"additional","affiliation":[{"name":"Cytometry and Biomarkers Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-7710","authenticated-orcid":false,"given":"Mariette","family":"Matondo","sequence":"additional","affiliation":[{"name":"Plateforme Prot\u00e9omique, Unit\u00e9 de Spectrom\u00e9trie de Masse pour la Biologie (MSBio), CNRS UMR 2000 Centre de Ressources et Recherches Technologiques (C2RT), Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6479-9470","authenticated-orcid":false,"given":"G\u00e9rard","family":"P\u00e9hau\u2010Arnaudet","sequence":"additional","affiliation":[{"name":"Ultrastructural Bio\u2010Imaging, UTechS UBI, CNRS UMR 3528 D\u00e9partement de Biologie cellulaire et infection, Institut Pasteur, F\u201075015  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia C. 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