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In our study, we found that exosomes were aroused by \u03b2\u2010catenin in renal tubular cells. Osteopontin (OPN), especially its N\u2010terminal fragment (N\u2010OPN), was encapsulated in \u03b2\u2010catenin\u2010controlled tubular cell\u2010derived exosome cargo, and subsequently passed to fibroblasts. Through binding with CD44, exosomal OPN promoted fibroblast proliferation and activation. Gene deletion of \u03b2\u2010catenin in tubular cells (Ksp\u2010\u03b2\u2010catenin<jats:sup>\u2212\/\u2212<\/jats:sup>) or gene ablation of CD44 (CD44<jats:sup>\u2212\/\u2212<\/jats:sup>) greatly ameliorated renal fibrosis. Notably, N\u2010OPN was carried by exosome and secreted into the urine of patients with CKD, and negatively correlated with kidney function. The urinary exosomes from patients with CKD greatly accelerated renal fibrosis, which was blocked by CD44 deletion. These results suggest that exosome\u2010mediated activation of the OPN\/CD44 axis plays a key role in renal fibrosis, which is controlled by \u03b2\u2010catenin.<\/jats:p>","DOI":"10.1002\/jev2.12203","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T10:47:15Z","timestamp":1647859635000},"source":"Crossref","is-referenced-by-count":103,"title":["\u03b2\u2010catenin\u2010controlled tubular cell\u2010derived exosomes play a key role in fibroblast activation via the OPN\u2010CD44 axis"],"prefix":"10.1002","volume":"11","author":[{"given":"Shuangqin","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangdong Provincial Key Laboratory of Nephrology, Division of Nephrology Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Division of Nephrology, Ruikang 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