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Currently, no practical therapeutic approach is available to prevent PE progression, except for early delivery. Gut dysbiosis is associated with PE development. Previous data showed that the abundance of <jats:italic>Akkermansia muciniphila<\/jats:italic> (<jats:italic>Am<\/jats:italic>) was lower in patients with PE than in normotensive pregnant women. Here, in this study, decreased abundance of <jats:italic>Am<\/jats:italic> was observed in a PE mouse model. Also, we found that administration with <jats:italic>Am<\/jats:italic> could significantly attenuate systolic blood pressure, promote foetal growth and improve the placental pathology in mice with PE. Moreover, <jats:italic>Am<\/jats:italic>\u2010derived extracellular vesicles (AmEVs) were transferred from the gastrointestinal (GI) tract to the placenta and mitigated pre\u2010eclamptic symptoms in PE mice. These beneficial effects of AmEVs were mediated by enhanced trophoblast invasion of the spiral artery (SpA) and SpA remodelling through activation of the epidermal growth factor receptor (EGFR)\u2013phosphatidylinositol\u20103\u2010kinase (PI3K)\u2013protein kinase B (AKT) signalling pathway. Collectively, our findings revealed the potential benefit of using AmEVs for PE treatment and highlighted important host\u2013microbiota interactions.<\/jats:p>","DOI":"10.1002\/jev2.12328","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T06:35:41Z","timestamp":1683786941000},"source":"Crossref","is-referenced-by-count":84,"title":["Extracellular vesicles derived from <i>Akkermansia muciniphila<\/i> promote placentation and mitigate preeclampsia in a mouse model"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-9760","authenticated-orcid":false,"given":"Yun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nanfang Hospital, Southern Medical University  Guangzhou Guangdong 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