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One potentially contributing factor is A Disintegrin and Metalloprotease 17 (ADAM17)\u2014itself being able to promote chemoresistance and inducing tumour cell proliferation and survival via the Epidermal Growth Factor Receptor (EGFR) pathway by shedding several of its ligands including Amphiregulin (AREG). We now demonstrate that upon chemotherapeutic treatment, proteolytically active ADAM17 is released in association with EV from OvCa cells. In terms of function, we show that patient\u2010derived EV induce AREG shedding and restore chemoresistance in ADAM17\u2010deficient cells. 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