{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:17:19Z","timestamp":1790813839844,"version":"4.1.0"},"reference-count":131,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Brain\u2010derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD), relaying important physiological information about their host tissues. The internal cargo of EVs is protected from degradation, making EVs attractive AD biomarkers. However, it is unclear how circulating EVs relate to EVs isolated from disease\u2010vulnerable brain regions. We developed a novel method for collecting EVs from the hippocampal interstitial fluid (ISF) of live mice. EVs (EV\n                    <jats:sup>ISF<\/jats:sup>\n                    ) were isolated via ultracentrifugation and characterized by nanoparticle tracking analysis, immunogold labelling, and flow cytometry. Mass spectrometry and proteomic analyses were performed on EV\n                    <jats:sup>ISF<\/jats:sup>\n                    cargo. EV\n                    <jats:sup>ISF<\/jats:sup>\n                    were 40\u2013150\u00a0nm in size and expressed CD63, CD9, and CD81. Using a model of cerebral amyloidosis (e.g.,\n                    <jats:italic>APPswe<\/jats:italic>\n                    ,\n                    <jats:italic>PSEN1dE9<\/jats:italic>\n                    mice), we found protein concentration increased but protein diversity decreased with A\u03b2 deposition. Genotype, age, and A\u03b2 deposition modulated proteostasis\u2010 and immunometabolic\u2010related pathways. Changes in the microglial EV\n                    <jats:sup>ISF<\/jats:sup>\n                    proteome were sexually dimorphic and associated with a differential response of plaque associated microglia. We found that female APP\/PS1 mice have more amyloid plaques, less plaque associated microglia, and a less robust\u2010 and diverse\u2010 EV\n                    <jats:sup>ISF<\/jats:sup>\n                    microglial proteome. Thus, in vivo microdialysis is a novel technique for collecting EV\n                    <jats:sup>ISF<\/jats:sup>\n                    and offers a unique opportunity to explore the role of EVs in AD.\n                  <\/jats:p>","DOI":"10.1002\/jev2.12398","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T22:48:59Z","timestamp":1704754139000},"source":"Crossref","is-referenced-by-count":25,"title":["Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EV\n                    <sup>ISF<\/sup>\n                    ) reveals sex\u2010dependent changes in microglial EV proteome in response to A\u03b2 pathology"],"prefix":"10.1002","volume":"13","author":[{"given":"Morgan C.","family":"Pait","sequence":"first","affiliation":[{"name":"Department of Physiology &amp; Pharmacology Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah 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