{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:18:24Z","timestamp":1792725504804,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972755"],"award-info":[{"award-number":["31972755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020KH031"],"award-info":[{"award-number":["ZR2020KH031"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extracellular vesicles (EVs) exert a significant influence not only on the pathogenesis of diseases but also on their therapeutic interventions, contingent upon the variances observed in their originating cells. Mitochondria can be transported between cells via EVs to promote pathological changes. In this study, we found that EVs derived from M1 macrophages (M1\u2010EVs), which encapsulate inflammatory mitochondria, can penetrate pancreatic beta cells. Inflammatory mitochondria fuse with the mitochondria of pancreatic beta cells, resulting in lipid peroxidation and mitochondrial disruption. Furthermore, fragments of mitochondrial DNA (mtDNA) are released into the cytosol, activating the STING pathway and ultimately inducing apoptosis. The potential of adipose\u2010derived stem cell (ADSC)\u2010released EVs in suppressing M1 macrophage reactions shows promise. Subsequently, ADSC\u2010EVs were utilized and modified with an F4\/80 antibody to specifically target macrophages, aiming to treat ferroptosis of pancreatic beta cells in vivo. In summary, our data further demonstrate that EVs secreted from M1 phenotype macrophages play major roles in beta cell ferroptosis, and the modified ADSC\u2010EVs exhibit considerable potential for development as a vehicle for targeted delivery to macrophages.<\/jats:p>","DOI":"10.1002\/jev2.12410","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:48:28Z","timestamp":1707274108000},"source":"Crossref","is-referenced-by-count":96,"title":["Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuhua","family":"Gao","sequence":"first","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"},{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Mi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, College of Veterinary Medicine Zhejiang A&amp;F University  Lin'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhou","family":"Fan","sequence":"additional","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangwei","family":"Liao","sequence":"additional","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Ming","sequence":"additional","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Guan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, College of Veterinary Medicine Zhejiang A&amp;F University  Lin'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-6060","authenticated-orcid":false,"given":"Chunyu","family":"Bai","sequence":"additional","affiliation":[{"name":"Precision Medicine Laboratory for Chronic Non\u2010communicable Diseases of Shandong Province, Institute of Precision Medicine Jining Medical University  Jining Shandong China"},{"name":"Institute of Animal Sciences Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9130-3_5"},{"issue":"4","key":"e_1_2_9_3_1","article-title":"Mitochondrial transfer regulates cell fate through metabolic remodeling in osteoporosis","volume":"10","author":"Cai W. J.","year":"2023","journal-title":"Advancement of Science"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.07.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.771298"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1081"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305062"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24799-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.038"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.08.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.10.042"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.09.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166114"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29400"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2647"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.90777"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1025709"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01273-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12769"},{"key":"e_1_2_9_21_1","article-title":"M2\u2010like macrophages transplantation protects against the doxorubicin\u2010induced heart failure via mitochondrial transfer","author":"Liu Y. H.","year":"2022","journal-title":"Biomaterials Research"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12455"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky869"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0151-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.031"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.08.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.040"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.12.010"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0087-5"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000236734.39241.99"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00669-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704862114"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav9141"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4950-x"},{"key":"e_1_2_9_36_1","first-page":"273","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism","volume":"171","author":"Stockwell B. R.","year":"2017","journal-title":"Redox Biology, and Disease. Cell"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132747"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169756"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1697028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0663-0"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.11.020"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0272"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12342"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102920"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01446-1"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe0083"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.07.011"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05770-w"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00613-4"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.12410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:22:42Z","timestamp":1760624562000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.12410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jev2.12410"],"URL":"https:\/\/doi.org\/10.1002\/jev2.12410","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"article-number":"e12410"}}