{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:22:26Z","timestamp":1793424146450,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["CRC 950\u2010232249 Tier 1"],"award-info":[{"award-number":["CRC 950\u2010232249 Tier 1"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R01HD089660"],"award-info":[{"award-number":["1R01HD089660"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Small\u2010for\u2010gestational age (SGA) neonates exhibit increased perinatal morbidity and mortality, and a greater risk of developing chronic diseases in adulthood. Currently, no effective maternal blood\u2010based screening methods for determining SGA risk are available. We used a high\u2010resolution MS\/MS<jats:sup>ALL<\/jats:sup> shotgun lipidomic approach to explore the lipid profiles of small extracellular vesicles (sEV)\u00a0released from the placenta into the circulation of pregnant individuals. Samples were acquired from 195 normal and 41 SGA pregnancies. Lipid profiles were determined serially across pregnancy. We identified specific lipid signatures of placental sEVs that define the trajectory of a normal pregnancy and their changes occurring in relation to maternal characteristics (parity and ethnicity) and birthweight centile. We constructed a multivariate model demonstrating that specific lipid features of circulating placental sEVs, particularly during early gestation, are highly predictive of SGA infants. Lipidomic\u2010based biomarker development promises to improve the early detection of pregnancies at risk of developing SGA, an unmet clinical need in obstetrics.<\/jats:p>","DOI":"10.1002\/jev2.12413","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T08:24:01Z","timestamp":1707899041000},"source":"Crossref","is-referenced-by-count":15,"title":["Lipid profile of circulating placental extracellular vesicles during pregnancy identifies foetal growth restriction risk"],"prefix":"10.1002","volume":"13","author":[{"given":"Miira M.","family":"Klemetti","sequence":"first","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Obstetrics &amp; Gynecology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ante B. V.","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Program in Translational Medicine, Peter Gilgan Centre for Research and Learning Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aafaque","family":"Ahmad Khan","sequence":"additional","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Ermini","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler R.","family":"Porter","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Litvack","sequence":"additional","affiliation":[{"name":"Program in Translational Medicine, Peter Gilgan Centre for Research and Learning Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruthi","family":"Alahari","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Zamudio","sequence":"additional","affiliation":[{"name":"Placental Research Group LLC  Maplewood New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Illsley","sequence":"additional","affiliation":[{"name":"Placental Research Group LLC  Maplewood New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"R\u00f6st","sequence":"additional","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Post","sequence":"additional","affiliation":[{"name":"Program in Translational Medicine, Peter Gilgan Centre for Research and Learning Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Department Physiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-2359","authenticated-orcid":false,"given":"Isabella","family":"Caniggia","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Obstetrics &amp; Gynecology University of Toronto Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Department Physiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.12.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11112"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20100360\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214121"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.02.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57144"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010020\u201000299\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200348"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163972"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017\u201000152"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002199"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20101288"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9124"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.227"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.12172"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.12.020"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06\u20107016com"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012491\u20104"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.652651"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110041"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.02.016"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f108"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.02.037"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006261"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012245.pub2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201015666140330192345"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4626"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023487"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002228"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D003715"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3712"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.12.1105"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e35"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600624786"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(13)70006\u20108"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010031238"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145794"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1034414"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12311"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpim.17"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.02.006"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031832\u20105"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.07.001"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000388"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306\u2010020\u201001740\u20109"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12239"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.09.008"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017\u201000876"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.593962"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15\u20100966"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.841278"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.08.003"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.05.009"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.10.011"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R084343"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2017.03.001"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.07.002"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100804\u20109"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00131\u20102"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys139"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.11.008"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2016.08.008"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.043"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R083915"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(11)90690\u20105"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147360"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.12413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:22:41Z","timestamp":1760624561000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.12413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jev2.12413"],"URL":"https:\/\/doi.org\/10.1002\/jev2.12413","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"article-number":"e12413"}}