{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:53:24Z","timestamp":1793976804020,"version":"4.8.0"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014791","name":"H\u00f6gskolan i Sk\u00f6vde","doi-asserted-by":"publisher","award":["grant # 20200014"],"award-info":[{"award-number":["grant # 20200014"]}],"id":[{"id":"10.13039\/501100014791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for cardiac repair and determine the most effective one, which nowadays remains limited. We comprehensively assessed the efficacy of sEV obtained from human primary bone marrow mesenchymal stromal cells (BM\u2010MSC), human immortalized MSC (hTERT\u2010MSC), human embryonic stem cells (ESC), ESC\u2010derived cardiac progenitor cells (CPC), human ESC\u2010derived cardiomyocytes (CM), and human primary ventricular cardiac fibroblasts (VCF), in in vitro models of cardiac repair. ESC\u2010derived sEV (ESC\u2010sEV) exhibited the best pro\u2010angiogenic and anti\u2010fibrotic effects in vitro. Then, we evaluated the functionality of the sEV with the most promising performances in vitro, in a murine model of MI\u2010reperfusion injury (IRI) and analysed their RNA and protein compositions. In vivo, ESC\u2010sEV provided the most favourable outcome after MI by reducing adverse cardiac remodelling through down\u2010regulating fibrosis and increasing angiogenesis. Furthermore, transcriptomic, and proteomic characterizations of sEV derived from hTERT\u2010MSC, ESC, and CPC revealed factors in ESC\u2010sEV that potentially drove the observed functions. In conclusion, ESC\u2010sEV holds great promise as a cell\u2010free treatment for promoting cardiac repair following MI.<\/jats:p>","DOI":"10.1002\/jev2.12445","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T02:25:26Z","timestamp":1715048726000},"source":"Crossref","is-referenced-by-count":42,"title":["Head\u2010to\u2010head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-9484","authenticated-orcid":false,"given":"Hern\u00e1n","family":"Gonz\u00e1lez\u2010King","sequence":"first","affiliation":[{"name":"Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&amp;D, AstraZeneca M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Research 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