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The cysticerci of <jats:italic>T. solium<\/jats:italic> causes infection in the central nervous system known as neurocysticercosis (NCC), which affects a significant population in developing countries. Extracellular vesicles (EVs) are 30\u2013150\u2010nm\u2010sized particles and constitute a significant part of the secretome. However, the role of EV in NCC pathogenesis remains undetermined. Here, for the first time, we report that EV from <jats:italic>T. solium<\/jats:italic> larvae is abundant in metabolites that can negatively regulate PI3K\/AKT pathway, efficiently internalized by macrophages to induce AKT and mTOR degradation through auto\u2010lysosomal route with a prominent increase in the ubiquitination of both proteins. This results in less ROS production and diminished bacterial killing capability among EV\u2010treated macrophages. Due to this, both macro\u2010autophagy and caspase\u2010linked apoptosis are upregulated, with a reduction of the autophagy substrate sequestome 1. In summary, we report that <jats:italic>T. solium<\/jats:italic> EV from viable cysts attenuates the AKT\u2013mTOR pathway thereby promoting apoptosis in macrophages, and this may exert immunosuppression during an early viable stage of the parasite in NCC, which is primarily asymptomatic. Further investigation on EV\u2010mediated immune suppression revealed that the EV can protect the mice from DSS\u2010induced colitis and improve colon architecture. These findings shed light on the previously unknown role of <jats:italic>T. solium<\/jats:italic> EV and the therapeutic role of their immune suppression potential.<\/jats:p>","DOI":"10.1002\/jev2.12448","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T03:41:11Z","timestamp":1716435671000},"source":"Crossref","is-referenced-by-count":11,"title":["<i>Taenia solium<\/i> cysticerci's extracellular vesicles Attenuate the AKT\/mTORC1 pathway for Alleviating DSS\u2010induced colitis in a murine model"],"prefix":"10.1002","volume":"13","author":[{"given":"Suraj Singh","family":"Rawat","sequence":"first","affiliation":[{"name":"School of Biosciences and Bioengineering Indian Institute of Technology Mandi  Mandi Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand Kumar","family":"Keshri","sequence":"additional","affiliation":[{"name":"School of Biosciences and Bioengineering Indian Institute of Technology Mandi  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