{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:50:40Z","timestamp":1790833840635,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current study aimed to investigate the effects of human placental mesenchymal stromal cell\u2010derived small extracellular vesicles (hPMSC\u2010sEVs) as a treatment for COVID\u201019. This double\u2010blind, randomized, controlled clinical trial was conducted on two groups of patients with COVID\u201019\u2010associated acute respiratory distress syndrome. After randomization, the control group received standard treatment and placebo, and the intervention arm received standard treatment plus hPMSC\u2010sEVs. The number of hospital deaths was considered the primary outcome. After meeting the exclusion and inclusion criteria, 21 and 24 patients were allocated to intervention and control arms, respectively. Besides admission SpO<jats:sub>2<\/jats:sub> levels, which were significantly lower in the intervention arm (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), all the baseline demo\u2010biographic and laboratory variables were similar between the groups. It was shown that hPMSC\u2010sEVs could significantly (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015) decrease the mortality ratio in the intervention group (4\/21 [19.04%]) compared to the controls (13\/24 [54.16%]). The mean time to death in the intervention and control groups was 28.06 and 11.10 days, respectively (<jats:italic>p<\/jats:italic> &lt;\u00a00.001). This study showed that hPMSC\u2010sEVs are a possible treatment for critically ill patients with COVID\u201019.<\/jats:p>","DOI":"10.1002\/jev2.12492","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T08:38:21Z","timestamp":1721896701000},"source":"Crossref","is-referenced-by-count":49,"title":["Human placental mesenchymal stromal cell\u2010derived small extracellular vesicles as a treatment for severe COVID\u201019: A double\u2010blind randomized controlled clinical trial"],"prefix":"10.1002","volume":"13","author":[{"given":"Mohammad Hossein","family":"Zamanian","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Norooznezhad","sequence":"additional","affiliation":[{"name":"Medical Biology Research Centre, Health Technology Institute Kermanshah University of Medical Sciences  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