{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:17:05Z","timestamp":1792289825294,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mesenchymal stem cell (MSC)\u2010derived extracellular vesicles (EVs) have shown anti\u2010inflammatory potential in multiple inflammatory diseases. In the March 2022 issue of the\n                    <jats:italic>Journal of Extracellular Vesicles<\/jats:italic>\n                    , it was shown that EVs from human MSCs can suppress severe acute respiratory distress syndrome, coronavirus 2 (SARS\u2010CoV\u20102) replication and can mitigate the production and release of infectious virions. We therefore hypothesized that MSC\u2010EVs have an anti\u2010viral effect in SARS\u2010CoV\u20102 infection in vivo. We extended this question to ask whether also other respiratory viral infections could be treated by MSC\u2010EVs. Adipose stem cell\u2010derived EVs (ASC\u2010EVs) were isolated using tangential flow filtration from conditioned media obtained from a multi\u2010flask cell culture system. The effects of the ASC\u2010EVs were tested \u00a0in Vero E6 cells in vitro. ASC\u2010EVs were also given i.v. to SARS\u2010CoV\u20102 infected Syrian Hamsters, and H1N1 influenza virus infected mice. The ASC\u2010EVs attenuated SARS\u2010CoV\u20102 virus replication in Vero E6 cells and reduced body weight and signs of lung injury in infected Syrian hamsters. Furthermore, ASC\u2010EVs increased the survival rate of influenza A\u2010infected mice and attenuated signs of lung injury. In summary, this study suggests that ASC\u2010EVs can have beneficial therapeutic effects in models of virus\u2010infection\u2010associated acute lung injury and may potentially be developed to treat lung injury in humans.\n                  <\/jats:p>","DOI":"10.1002\/jev2.12495","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T08:28:42Z","timestamp":1725956922000},"source":"Crossref","is-referenced-by-count":34,"title":["Therapeutic potential of mesenchymal stem cell\u2010derived extracellular vesicles in SARS\u2010CoV\u20102 and H1N1 influenza\u2010induced acute lung injury"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9771-0642","authenticated-orcid":false,"given":"Jun Ho","family":"Lee","sequence":"first","affiliation":[{"name":"ExoCoBio Exosome Institute (EEI) ExoCoBio Inc., STE 306, 19 Gasan digital 1\u2010ro  Geumcheon\u2010gu Seoul Republic of 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