{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:31:11Z","timestamp":1783636271928,"version":"3.55.0"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370985"],"award-info":[{"award-number":["82370985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401162"],"award-info":[{"award-number":["82401162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301123"],"award-info":[{"award-number":["82301123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100600"],"award-info":[{"award-number":["2021YFA1100600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010626"],"award-info":[{"award-number":["2023A1515010626"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012820"],"award-info":[{"award-number":["2024A1515012820"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515111127"],"award-info":[{"award-number":["2023A1515111127"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010453"],"award-info":[{"award-number":["2025A1515010453"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Temporomandibular joint osteoarthritis (TMJ\u2010OA) is a progressive degenerative disorder, for which therapeutic interventions remain limited. The disruption of metabolic homeostasis plays a critical role in the pathogenesis and advancement of TMJ\u2010OA. However, it remains unclear whether extracellular vesicles (EVs) as cellular metabolites are correlated with the pathogenesis, treatment and diagnosis of TMJ\u2010OA. In this study, we demonstrated that autologous circulating extracellular vesicles (C\u2010EVs) possessed significant therapeutic potential for TMJ\u2010OA through the targeted removal of senescent chondrocytes. In a randomized clinical trial (ChiCTR2200063153), C\u2010EV administration was found to significantly enhance condylar bone regeneration and alleviate symptoms relative to hyaluronic acid controls, without eliciting any adverse effects. Comparative analysis revealed that joint cavity\u2010derived EVs from TMJ\u2010OA patients (OA\u2010EVs) exhibited structural abnormalities, diminished expression of canonical EV markers, and pro\u2010inflammatory characteristics. In contrast, C\u2010EVs were significantly enriched with functional proteins C1q binding protein (C1QBP). And the level of C1QBP\u2010positive EVs was positively correlated with therapeutic outcomes, thereby establishing C1QBP as a potential predictive biomarker for TMJ\u2010OA. Furthermore, C\u2010EVs reestablished joint homeostasis by regulating the immune microenvironment and tissue regeneration capacity. Mechanistically, C1QBP\n                    <jats:sup>high<\/jats:sup>\n                    C\u2010EVs upregulated the expression of membrane C1q on senescent chondrocytes, thereby initiating C1q\u2013C1QBP binding, p14ARF translocation to mitochondria, and subsequent cytochrome C\/caspase\u20103\u2010dependent apoptosis. Our findings demonstrate that C\u2010EVs serve a dual therapeutic role by facilitating the clearance of senescent cells\n                    <jats:italic>via<\/jats:italic>\n                    the C1QBP\/C1q\/p14ARF axis, while promoting tissue regeneration and regulating metabolites homeostasis, offering a novel biological strategy for TMJ\u2010OA treatment.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70224","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:12:57Z","timestamp":1769875977000},"source":"Crossref","is-referenced-by-count":1,"title":["Circulating Metabolites Treat Human TMJ\u2010OA by Eliminating Senescent Chondrocytes\n                    <i>via<\/i>\n                    the C1QBP\/C1q\/p14ARF Axis"],"prefix":"10.1002","volume":"15","author":[{"given":"Bowen","family":"Meng","sequence":"first","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"He","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Fu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"An","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhuo","family":"Hei","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyunbo","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Hao","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-7712","authenticated-orcid":false,"given":"Xueli","family":"Mao","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak Lal","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-7500","authenticated-orcid":false,"given":"Songtao","family":"Shi","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat\u2010Sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-9293","authenticated-orcid":false,"given":"Qingbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Temporomandibular Joint School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/13535.5826"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.141"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16932"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12574"},{"issue":"4","key":"e_1_2_11_6_1","first-page":"149","article-title":"[Arthrocentesis of the Temporomandibular Joint. Long\u2010Term Results]","volume":"47","author":"Cascone P.","year":"1998","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.116"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010020\u201000533\u20107"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000576\u20100"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2011.02233.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113201"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345860650111701"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101338"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.03.014"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20100378(01)00095\u2010x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)60802\u20103"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.52312\/jdrs.2023.901"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12260"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.06.041"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12428"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.04.002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010018\u20100123\u20104"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.01.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210815"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.003"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13141"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)02322\u20105"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010443"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aai8524"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001735\u20101"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010024\u201000138\u20104"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.08.034"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.05.001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010018\u20100070\u20102"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.015"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010019\u20100965\u20107"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.23.18287"},{"key":"e_1_2_11_39_1","doi-asserted-by":"crossref","unstructured":"Meng B. Y.Qu B.Yang et\u00a0al.2025.\u201cIntermittent Hypobaric Pressure Induces Selective Senescent Cells Death and Alleviates Age\u2010Related Osteoporosis.\u201d Nature Biomedical Engineering.https:\/\/doi.org\/10.1038\/s41551\u2010025\u201001584\u20105.","DOI":"10.1038\/s41551-025-01584-5"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.50"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","unstructured":"Mulcahy L. A. R. C.Pink andD. R.Carter.2014. \u201cRoutes and Mechanisms of Extracellular Vesicle Uptake.\u201d Journal of Extracellular Vesicles 3.https:\/\/doi.org\/10.3402\/jev.v3.24641.","DOI":"10.3402\/jev.v3.24641"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14040315"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025453\u20102"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.11.012"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200306"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2019.1656044"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002820\u2010x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.11.019"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010021\u201000143\u20102"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/16270943"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.001"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.01.017"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20775"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000460\u20103"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045036"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3569"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010023\u201001751\u20106"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03517"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1012112"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.026"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515574770"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100092\u20109"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.98763"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1158744"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010017\u20101312\u20107"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.62708"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.015"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000451\u20109"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100372\u20109"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.758386"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12240"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.09.076"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12109"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12344"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.70224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jev2.70224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.70224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:50:38Z","timestamp":1773010238000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.70224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jev2.70224"],"URL":"https:\/\/doi.org\/10.1002\/jev2.70224","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"article-number":"e70224"}}