{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:43:57Z","timestamp":1789839837351,"version":"4.0.1"},"reference-count":90,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endometriosis (EM) is a chronic inflammatory disease that affects \u223c10% of women during reproductive age. It is characterised by ectopic (ECT) growth of endometrial\u2010like tissue mainly in the pelvic cavity. Small extracellular vesicles (sEVs) mediate cellular interactions, but their function remains poorly understood in the pathogenesis of EM. 3D endometrial epithelial organoids (EEOs) from ECT lesions and eutopic (EUT) endometrium from EM patients and controls were established to investigate sEVs. Multiplex bead\u2010based flow cytometry revealed CD133\/1 and EpCAM as dominant markers on EEO\u2010sEVs, with ECT EEO\u2010sEVs showing upregulation of CD44, CD29 and downregulation of EpCAM compared to EUT EEO\u2010sEVs. Peritoneal fluid (PF)\u2010sEVs displayed high and correlated CD133\/1 and EpCAM expression, indicating a major contribution from endometrial epithelial (EE) cells, alongside sEVs of lymphocyte and endothelial origin. Functionally, both ECT EEO\u2010sEVs and PF\u2010sEVs from EM patients significantly suppressed macrophage phagocytosis, as assessed by pH\u2010sensitive fluorescent bioparticles. The effect was reversed by CD47 blockade. The coexpression of CD47 with CD133\/1 and EpCAM on PF\u2010sEVs indicates the involvement of EE cell\u2010derived sEVs in CD47\/SIRP\u2010\u03b1 mediated suppression. This study provides the first thorough characterisation of EE\u2010derived sEVs utilising EEO models in EM and demonstrates their potential immunomodulatory role in the peritoneal microenvironment via CD47\/SIRP\u2010\u03b1 signalling.<\/jats:p>","DOI":"10.1002\/jev2.70227","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:33:11Z","timestamp":1771515191000},"source":"Crossref","is-referenced-by-count":5,"title":["Human Endometriotic Lesion\u2010Derived Small Extracellular Vesicles Impair Macrophage Function in the Peritoneal Microenvironment"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-4054","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"first","affiliation":[{"name":"Oxford Endometriosis Care Centre, Nuffield Department of Women's &amp; Reproductive Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Jin","sequence":"additional","affiliation":[{"name":"Oxford Endometriosis Care Centre, Nuffield Department of Women's &amp; 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