{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:50:48Z","timestamp":1791384648289,"version":"4.3.3"},"reference-count":88,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["101095679"],"award-info":[{"award-number":["101095679"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00013"],"award-info":[{"award-number":["FORT23\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01804"],"award-info":[{"award-number":["PI18\/01804"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00883"],"award-info":[{"award-number":["PI19\/00883"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01248"],"award-info":[{"award-number":["PI21\/01248"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PI\u20100285\u20102016"],"award-info":[{"award-number":["PI\u20100285\u20102016"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016970","name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PI18\u2010RT\u20103364"],"award-info":[{"award-number":["PI18\u2010RT\u20103364"]}],"id":[{"id":"10.13039\/100016970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016970","name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["UMA18\u2010FEDERJA\u2010194"],"award-info":[{"award-number":["UMA18\u2010FEDERJA\u2010194"]}],"id":[{"id":"10.13039\/100016970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The role of extracellular vesicles secreted by the gut microbiota present in faeces (fEVs) is not well known in metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and idiosyncratic drug\u2010induced liver injury (DILI). We identify the microbiome profiles of fEVs in these liver diseases, and analyse the effects of fEVs from MASLD, without (F\u22642) or with (F\u22653) significant liver fibrosis, and DILI patients on inflammation, steatosis and mitochondrial function. DILI patients showed a consistent pattern in fEVs, characterised by a decrease in\n                    <jats:italic>Paraprevotella<\/jats:italic>\n                    and an increase in\n                    <jats:italic>AAP99, Acinetobacter, Actinobacillus, Aerococcus<\/jats:italic>\n                    and\n                    <jats:italic>Anaeroglobus<\/jats:italic>\n                    . A higher presence of 16S rDNA was observed in plasma EVs from MASLD and DILI patients. HepG2 cells treated with DILI and MASLD F\u22653 fEVs increased\n                    <jats:italic>TLR4<\/jats:italic>\n                    ,\n                    <jats:italic>TLR5<\/jats:italic>\n                    ,\n                    <jats:italic>IL6<\/jats:italic>\n                    and\n                    <jats:italic>CASP3<\/jats:italic>\n                    expression, and accumulation of lipid droplets. DILI fEVs enhanced the hepatotoxic impact of diclofenac on the response to microbial components (\n                    <jats:italic>TLR4<\/jats:italic>\n                    ,\n                    <jats:italic>TLR5<\/jats:italic>\n                    ), inflammatory response (\n                    <jats:italic>IL1B<\/jats:italic>\n                    ,\n                    <jats:italic>IL6<\/jats:italic>\n                    ), accumulation of lipid droplets and mitochondrial dysfunction (\n                    <jats:italic>OPA1<\/jats:italic>\n                    ,\n                    <jats:italic>DNM1L<\/jats:italic>\n                    ). In conclusion, bacterial EVs enter the bloodstream and could modulate the immune response. DILI and MASLD F\u22653 fEVs are drivers of the pro\u2010inflammatory response and hepatocyte steatosis. DILI fEVs have a distinct bacterial profile that enhances the hepatotoxic potential of diclofenac.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70240","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:35:34Z","timestamp":1773758134000},"source":"Crossref","is-referenced-by-count":3,"title":["An Exploratory Study on the Pathogenic Role of Faecal Extracellular Vesicles in Metabolic Dysfunction\u2010Associated Steatotic Liver Disease Progression and in Drug\u2010Induced Liver Injury"],"prefix":"10.1002","volume":"15","author":[{"given":"Antonio J.","family":"Ruiz\u2010Malag\u00f3n","sequence":"first","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Herraiz\u2010Vilela","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Pinazo\u2010Bandera","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"Toro\u2010Ortiz","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailec","family":"Ho\u2010Plagaro","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (ibs.GRANADA)  Granada Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de las Nieves  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Garrido\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Robles\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"},{"name":"Departamento de Medicina Facultad de Medicina Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Taminiau","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Fundamental and Applied Research for Animals &amp; Health (FARAH) Department of Food Microbiology University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Daube","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Fundamental and Applied Research for Animals &amp; Health (FARAH) Department of Food Microbiology University of Li\u00e8ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Sanabria\u2010Cabrera","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Servicio de Farmacologia Clinica Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"},{"name":"Departamento de Farmacolog\u00eda Facultad de Medicina Universidad de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Matilla\u2010Cabello","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Departamento de Farmacolog\u00eda Facultad de Medicina Universidad de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Lucena","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"},{"name":"Servicio de Farmacologia Clinica Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"},{"name":"Departamento de Farmacolog\u00eda Facultad de Medicina Universidad de M\u00e1laga M\u00e1laga Spain"},{"name":"UICEC IBIMA Plataforma de Investigaci\u00f3n Cl\u00ednica del ISCIII (SCReN, Spanish Clinical Research Network)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal J.","family":"Andrade","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"},{"name":"Departamento de Medicina Facultad de Medicina Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-2724","authenticated-orcid":false,"given":"Eduardo","family":"Garc\u00eda\u2010Fuentes","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Garc\u00eda\u2010Cortes","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"},{"name":"CIBER de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodriguez\u2010Diaz","sequence":"additional","affiliation":[{"name":"IBIMA Plataforma BIONAND, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga M\u00e1laga Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010306098"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.58"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u2010S002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100105\u20100"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21496"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374093"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.02.006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010230X\u20106\u201033"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2331460"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14952"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.11.037"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.01273\u201021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102893.2006.00736.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3480"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040818"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010019\u20100359\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1486793"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2423"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2017.1324731"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053279\u20101"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.02.013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020344"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12161"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10010015"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02663\u201022"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70017"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20102618\u20102\u201015"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12303"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu072"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00182.2014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R067595"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112571"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.575455"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010023\u20101988\u20108"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1196831"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010016\u20104079\u20104"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00484\u201021"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26709"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040584"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.2009.01669.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679\u2010022\u201000473\u20101"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010021\u201001440\u2010w"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.774335"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201004880\u2010x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3586"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462\u20102920.13401"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10360"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00080"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.01.010"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275\u2010012\u20101589\u20104"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416217"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.946422"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000468"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116210"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213675"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13080906"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/livers1030010"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16020295"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054971"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106348"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300666"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.145"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2584"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.5604\/16652681.1171749"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16121800"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01541\u201009"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.026"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv136"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425909342730"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203460"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114489"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u20102020\u2010ubih\u201005"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010018\u20100112\u20102"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010023\u201000875\u20105"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010023\u201000875\u20105"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010022\u201002242\u20101"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00362.2020"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S381667"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.934113"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004367\u20101"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010024\u201000959\u20109"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316733"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.70240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jev2.70240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.70240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:37:38Z","timestamp":1774255058000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.70240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/jev2.70240"],"URL":"https:\/\/doi.org\/10.1002\/jev2.70240","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"e70240"}}