{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:02:58Z","timestamp":1787738578093,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024250","name":"Israel Innovation Authority","doi-asserted-by":"publisher","award":["74260"],"award-info":[{"award-number":["74260"]}],"id":[{"id":"10.13039\/501100024250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Severe COVID\u201019, and other systemic infections, can trigger hyperinflammation leading to lung injury. EXO\u2010CD24, an inhaled extracellular vesicle therapy with anti\u2010inflammatory properties, has shown acute clinical benefit, but long\u2010term effects on survival remain unknown.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : We compared the mortality in 35 patients with moderate\u2010to\u2010severe COVID\u201019 treated with inhaled EXO\u2010CD24 on five consecutive days in 2020, versus 105 matched controls receiving standard care (1:3 ratio). This \u2018real life\u2019 study was a retrospective follow\u2010up extended to 4.6\u00a0years after infection, evaluating all\u2010cause mortality as well as health\u2010related quality of life in survivors (HRQoL).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : No deaths occurred in the EXO\u2010CD24 group (0\/35) versus 14 deaths (13.3%) among the matched controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). The survival difference was most marked in the first month but persisted over time. At the end of the follow\u2010up, theEXO\u2010CD24 patients reported significantly better HRQoL, including well\u2010being, physical function, and mobility.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Repeated inhalations with EXO\u2010CD24 is associated with improved survival and HRQoL up to 4.6\u00a0years post\u2010treatment. These findings suggest durable benefits and support further evaluation of EXO\u2010CD24 as an immunomodulatory therapy in severe inflammatory conditions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : ClinicalTrials.gov identifier: NCT04657497\n                  <\/jats:p>","DOI":"10.1002\/jev2.70253","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:21:11Z","timestamp":1773400871000},"source":"Crossref","is-referenced-by-count":3,"title":["Reduced Mortality in COVID\u201019 Patients Treated With Inhaled Extracellular Vesicles Expressing CD24"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-5910","authenticated-orcid":false,"given":"Shiran","family":"Shapira","sequence":"first","affiliation":[{"name":"The Health Promotion Center Tel Aviv Sourasky University Hospital  Tel Aviv Israel"},{"name":"Department of Molecular Genetics and Biochemistry, Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Vishnevsky","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine H Tel Aviv Sourasky University Hospital  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Yaakobi","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine E Tel Aviv Sourasky University Hospital  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Shenberg","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine H Tel Aviv Sourasky University Hospital  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mays","family":"Motlaq","sequence":"additional","affiliation":[{"name":"The Health Promotion Center Tel Aviv Sourasky University Hospital  Tel Aviv Israel"},{"name":"Department of Molecular Genetics and Biochemistry, Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Liberman","sequence":"additional","affiliation":[{"name":"The Health Promotion Center Tel Aviv Sourasky University Hospital  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminadav","family":"Kalisky","sequence":"additional","affiliation":[{"name":"The Health Promotion Center Tel Aviv Sourasky University Hospital  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadi","family":"Benari","sequence":"additional","affiliation":[{"name":"Maccabi Healthcare Services  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-4321","authenticated-orcid":false,"given":"Sotirios","family":"Tsiodras","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University General Hospital Attikon, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrod","family":"Adi","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit Tel\u2010Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-9249","authenticated-orcid":false,"given":"Jan","family":"L\u00f6tvall","sequence":"additional","affiliation":[{"name":"Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-9228","authenticated-orcid":false,"given":"Nadir","family":"Arber","sequence":"additional","affiliation":[{"name":"The Health Promotion Center Tel Aviv Sourasky University Hospital  Tel Aviv Israel"},{"name":"Department of Molecular Genetics and Biochemistry, Gray Faculty of Medical &amp; Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03553-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1456-0"},{"key":"e_1_2_10_4_1","volume-title":"Long\u00a0COVID or PostCOVID Conditions [Internet]","author":"Centers for Disease Control and Prevention","year":"2022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06394-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168988"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70351"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100433"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092523"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02759-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.06.024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2021.1982695"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19741-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2021.1866547"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0348-8"},{"issue":"6","key":"e_1_2_10_17_1","article-title":"A Novel Anti\u2010Inflammatory Exosome\u2010Based Therapy to Treat COVID\u201019","volume":"14","author":"Shapira S.","year":"2022","journal-title":"EMBO Molecular Medicine"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae756"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01292-y"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2021.1924397"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12492"}],"container-title":["Journal of Extracellular Vesicles"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.70253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jev2.70253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jev2.70253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:37:39Z","timestamp":1774255059000},"score":1,"resource":{"primary":{"URL":"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.70253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/jev2.70253"],"URL":"https:\/\/doi.org\/10.1002\/jev2.70253","archive":["Portico"],"relation":{},"ISSN":["2001-3078","2001-3078"],"issn-type":[{"value":"2001-3078","type":"print"},{"value":"2001-3078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"e70253"}}