{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:38:03Z","timestamp":1789616283395,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI22C0353"],"award-info":[{"award-number":["HI22C0353"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102023\u201000304686"],"award-info":[{"award-number":["RS\u20102023\u201000304686"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102025\u201025459033"],"award-info":[{"award-number":["RS\u20102025\u201025459033"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102025\u201025459146"],"award-info":[{"award-number":["RS\u20102025\u201025459146"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102023\u201000261820"],"award-info":[{"award-number":["RS\u20102023\u201000261820"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102023\u20100172"],"award-info":[{"award-number":["6\u20102023\u20100172"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early detection of colon adenocarcinoma (COAD) remains suboptimal. Fecal tests fail to diagnose 30% of stage I cancer, and serum CEA lacks sensitivity (&lt;\u00a040%). Extracellular vesicles (EVs) circulate systemically and package tumor\u2010related cargo, making them attractive non\u2010invasive biomarkers for cancer diagnosis. We profiled the EV proteome from 233 human patients using LC\u2010MS\/MS, including stage I\u2011IV tumors with matched non\u2011tumor colon tissues (\n                    <jats:italic>n<\/jats:italic>\n                    = 50 each;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0100), paired pre\u2011\/post\u2011operative plasma (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a090) and healthy plasma (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a043). Circulating EVs contained both tumor\u2010specific and stromal\/immune cell\u2010derived proteins, reflecting the systemic nature of EV biology in the cancer setting. Proteomic analysis identified 745 proteins enriched in tumor\u2010derived EVs (e.g., SRPK1, THBS2) and 127 proteins enriched in adjacent tissues. Plasma EVs revealed 166 proteins enriched in COAD (e.g., UBA1, FCN1) and 233 enriched in healthy controls. Pathway analysis linked tumor EV cargo to angiogenesis, mRNA splicing, TGF\u2011\n                    <jats:italic>\u03b2<\/jats:italic>\n                    signalling and RNA translation. Notably, a cross\u2010cancer comparison (pancreatic\u00a0=\u00a010, lung\u00a0=\u00a014 cases) revealed that 76% of tumor EV proteins were COAD\u2010specific, highlighting tissue of origin specificity. We further developed a 10\u2010protein EV panel comprising seven tumor\u2010associated and three healthy\u2010enriched EV proteins, which effectively distinguished COAD patients from healthy controls in the two validation cohorts (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0104 and\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0215), achieving\u00a0&gt;\u00a090% sensitivity for differentiating COAD from healthy and non\u2010COAD colorectal conditions. Six weeks after curative resection, tumor\u2010associated EV proteins decreased by &gt;\u00a070%, whereas healthy\u2010associated proteins rebounded to baseline, indicating surgical responsiveness. Collectively, EV protein signatures provide a sensitive and tissue\u2010specific window into tumor\u2013host communication, further supporting blood\u2010based early detection of COAD.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70278","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:47:27Z","timestamp":1776160047000},"source":"Crossref","is-referenced-by-count":1,"title":["Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8830-0442","authenticated-orcid":false,"given":"Yura","family":"Seo","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Graduate School of Medical Science, Brain Korea 21 FOUR Project, Severance Biomedical Science Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Dae","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-5824","authenticated-orcid":false,"given":"Linda","family":"Bojmar","sequence":"additional","affiliation":[{"name":"Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center Weill Cornell Medicine  New York New York USA"},{"name":"Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010A","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Graduate School of Medical Science, Brain Korea 21 FOUR Project, Severance Biomedical Science Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurin","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Graduate School of Medical Science, Brain Korea 21 FOUR Project, Severance Biomedical Science Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeyul K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Graduate School of Medical Science, Brain Korea 21 FOUR Project, Severance Biomedical Science Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Graduate School of Medical Science, Brain Korea 21 FOUR Project, Severance Biomedical Science Institute Yonsei University College of Medicine  Seoul Republic of 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