{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:26:18Z","timestamp":1786112778842,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370900"],"award-info":[{"award-number":["82370900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170575"],"award-info":[{"award-number":["82170575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer cachexia (CC) is a complex pathological condition associated with cancer progression and poor prognosis, particularly in gastrointestinal cancers, and is closely linked to the gut microbiota. Lipolysis in CC may play a key role in driving cachexia progression. However, the role of the gut microbiota in CC\u2010induced lipolysis and the underlying mechanisms remains unclear. In this study, we found that significant gut microbiota dysbiosis in pancreatic cancer cachexia, characterized by diminished abundance of\n                    <jats:italic>Eubacterium rectale<\/jats:italic>\n                    (\n                    <jats:italic>E.rectale<\/jats:italic>\n                    ), was negatively associated with lipolysis severity. Furthermore, we demonstrated for the first time that\n                    <jats:italic>E. rectale<\/jats:italic>\n                    derived extracellular vesicles (EVs) can ameliorate lipolysis across multiple CC models. Mechanistically, these effects are mediated by modulating pro\u2010inflammatory macrophages through inhibition of NF\u2010kB signalling, reducing macrophage polarization and inflammatory cytokine secretion. Our findings indicated\n                    <jats:italic>E. rectale<\/jats:italic>\n                    EVs could offer potential therapeutic benefits for CC and emphasize the importance of host\u2010microbiota interactions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : This study was registered at ClinicalTrials.gov (NCT06378853).\n                  <\/jats:p>","DOI":"10.1002\/jev2.70293","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:50:07Z","timestamp":1778050207000},"source":"Crossref","is-referenced-by-count":0,"title":["The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage 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