{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:54:59Z","timestamp":1789840499499,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012612","name":"Tianjin Research Program of Application Foundation and Advanced Technology of China","doi-asserted-by":"publisher","award":["24JCZDJC01310"],"award-info":[{"award-number":["24JCZDJC01310"]}],"id":[{"id":"10.13039\/501100012612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012612","name":"Tianjin Research Program of Application Foundation and Advanced Technology of China","doi-asserted-by":"publisher","award":["S22ZDF291"],"award-info":[{"award-number":["S22ZDF291"]}],"id":[{"id":"10.13039\/501100012612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Temporomandibular joint osteoarthritis (TMJ\u2010OA) is highly prevalent with an insidious onset. Severe inflammation and significant degenerative changes are often associated with the condition, and current clinical treatments remain inadequate. In this study, we focus on pyroptosis and engineered the camouflage protein (GSDMD\u2010C) attached to the membrane surface of small extracellular vesicles (sEVs)\u2013sEV\u2010p. sEV\u2010p has two key effects: firstly, the inherent immunomodulatory and nutritional support properties of sEVs promote the recovery of cellular function under pathological conditions; secondly, camouflage protein bind to the activated caspase\u20101, reducing the cleavage of endogenous GSDMD. The therapeutic effects of sEV\u2010p were evaluated through\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments and treatment of TMJ\u2010OA models in mice and Bama pigs. We further elucidated the mechanisms by single\u2010cell RNA sequencing analysis. Results show that sEV\u2010p alleviates the abnormal activation of inflammatory factors induced by pyroptosis, accompanied by a reduction in the proportion of inflammatory cells and a mitigation of acute inflammatory responses.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70342","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T02:18:08Z","timestamp":1786328288000},"source":"Crossref","is-referenced-by-count":1,"title":["Camouflage Protein\u2010Engineered Extracellular Vesicles Alleviate TMJ\u2010OA by Hijacking Caspase\u20101 to Suppress Pyroptosis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yufei","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"},{"name":"Key Laboratory of Oral Functional Reconstruction  Tianjin Tianjin China"},{"name":"Department of Occlusion and Temporomandibular Joint Disease Tianjin Stomatological Hospital, School of Medicine, Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Functional Reconstruction  Tianjin Tianjin China"},{"name":"Department of Occlusion and Temporomandibular Joint Disease Tianjin Stomatological Hospital, School of Medicine, Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimin","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianke","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioactive Materials, School of Life Sciences Ministry of Education Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanju","family":"Xu","sequence":"additional","affiliation":[{"name":"Hebei Naco Biotechnology Co. 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