{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:00:01Z","timestamp":1790791201366,"version":"4.1.0"},"reference-count":102,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_197677"],"award-info":[{"award-number":["320030_197677"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_197677"],"award-info":[{"award-number":["320030_197677"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Extracellular vesicles (EVs) are emerging as key mediators of disease\u2010associated intercellular communication and as promising biomarker sources across many disease conditions, including joint disorders such as rheumatoid arthritis (RA) and osteoarthritis (OA). Molecular profiling of synovial tissue has uncovered disease\u2010driving cellular states, but tissue biopsies are invasive and not routinely available. EVs in synovial fluid may offer a minimally invasive and complementary window into joint pathobiology. However, the molecular complexity of synovial fluid and the heterogeneity of EV populations have hindered the analysis of defined disease\u2010relevant EV subsets. To address this challenge, we developed a refined size\u2010exclusion chromatography\u2010ultrafiltration (SEC\u2010UF) workflow coupled to magnetic bead\u2010based immunocapture for targeted enrichment of cell type\u2010associated EV subpopulations from arthritic synovial fluid. As proof\u2010of\u2010concept, we targeted a stromal\u2010associated EV population using CD90\/THY1, a surface marker expressed by discrete synovial fibroblasts subsets implicated in arthritis pathobiology. In vitro validation using synovial fibroblast\u2010derived EVs confirmed surface\u2010accessible CD90 and demonstrated selective immunocapture of defined EV subpopulations. Application to patient\u2010derived synovial fluid showed that SEC\u2010UF pre\u2010enrichment improves the robustness of CD90\n                    <jats:sup>+<\/jats:sup>\n                    EV recovery from this complex biofluid. Liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) profiling established broad EV\u2010associated proteome coverage in synovial fluid (SF)\u2010EV preparations and identified multiple proteins reflecting the inflamed arthritic synovial environment. Fraction\u2010resolved proteomics enabled comparison of the CD90\u2010immunocaptured SF\u2010EV subset with the non\u2010captured CD90\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/CD90\n                    <jats:sup>low<\/jats:sup>\n                    SF\u2010EV pool. Differential proteomics and surfaceome\u2010informed cell\u2010of\u2010origin analysis supported enrichment of stromal\u2010associated surface markers in the CD90\n                    <jats:sup>+<\/jats:sup>\n                    fraction, whereas the non\u2010captured SF\u2010EV pool retained broader immune\u2010associated and residual stromal EV inputs. Together, this fit\u2010for\u2010purpose workflow provides a strategy to resolve EV heterogeneity patient synovial fluid and supports future biomarker\u2010oriented studies of defined subpopulations in arthritic diseases.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70353","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:49:36Z","timestamp":1790790576000},"source":"Crossref","is-referenced-by-count":0,"title":["Enrichment and Proteomic Profiling of Stromal\u2010Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size\u2010Exclusion Chromatography Coupled to CD90\u2010Directed Immunocapture"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0828-5132","authenticated-orcid":false,"given":"Stefanie","family":"Kurth","sequence":"first","affiliation":[{"name":"Experimental Rheumatology University of Basel  Basel Switzerland"},{"name":"Department of Biomedicine University of Basel  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