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Innovative strategies are urgently required to enhance anti\u2010tumour immune potency for clinical improvements in immunotherapy\u2010resistant malignancies. Herein, we developed pyroptosis\u2010amplified decoy nanovesicles (PADVs) to synergistically dismantle tumour resistance mechanisms and rejuvenate endogenous anti\u2010tumour immunity. PADVs integrate checkpoint\u2010neutralizing capability with precise regulation of the pyroptosis molecular switch in tumour cells, thereby initiating a sequential activation cascade that enables efficient presentation of tumour\u2010specific antigens to the reshaped immune system. Systemically infused PADVs demonstrated dual\u2010targeting priority towards lymph node and deep tumour tissues, reversing immunosuppression through competitive blockade of PD\u20101\/PD\u2010L1 and SIRP\u03b1\/CD47 axes while providing co\u2010stimulatory signals for immune reactivation. Furthermore, PADVs alleviate the epigenetic suppression of pyroptosis in tumours via cytosolic delivery of decitabine and LPS, enabling gasdermin D (GSDMD) upregulation and cleavage. This coordinated strategy reverses T cell exhaustion and triggers explosive antigen release via GSDMD\u2010mediated membrane perforation, initiating a self\u2010amplifying immune cascade involving dendritic cell activation, effector and memory T cell formation. Consequently, PADVs demonstrate excellent efficacy in suppressing tumour progression, recurrence, and metastasis in melanoma, breast cancer, and colon cancer models. This study pioneers a versatile nanoplatform that not only counteracts tumour immune evasion but also establishes durable anti\u2010tumour immunity, offering a transformative approach to tumour immunotherapy.<\/jats:p>","DOI":"10.1002\/jev2.70356","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:26:30Z","timestamp":1787901990000},"source":"Crossref","is-referenced-by-count":0,"title":["Pyroptosis\u2010Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Geng","family":"Dou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Oral Biology &amp; Clinic of Oral Rare Diseases and Genetic Disease School of Stomatology The Fourth 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