{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:48:57Z","timestamp":1791654537274,"version":"4.3.4"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82525039(J.H.)"],"award-info":[{"award-number":["82525039(J.H.)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472418(B.X.)"],"award-info":[{"award-number":["82472418(B.X.)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372404(J.H.)"],"award-info":[{"award-number":["82372404(J.H.)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430077(Z.L.)"],"award-info":[{"award-number":["82430077(Z.L.)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502883(S.L.)"],"award-info":[{"award-number":["82502883(S.L.)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472417(T.M.)"],"award-info":[{"award-number":["82472417(T.M.)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Spinal cord injury (SCI) poses a formidable challenge in regenerative medicine, with current therapeutic strategies proving largely unsuccessful in achieving functional repair. Notably, paediatric patients and neonatal mice exhibit spontaneous and efficient regeneration after SCI, while the mechanisms remain elusive. Through integrated multi\u2010omics analysis in neonatal, adult and aged mice with SCI, we discovered that the regeneration time window, inflammatory response, and intercellular communication are all age\u2010dependent. Neonatal spinal cord\u2010derived extracellular vesicles (nSC\u2010EVs) were identified carrying a regenerative protein signature and were critical mediators in restoring SCI repair in neonatal mice. Functionally, nSC\u2010EVs promote neurogenesis\n                    <jats:italic>via<\/jats:italic>\n                    the Wnt\/\u03b2\u2010catenin pathway and mediate axonal growth through the core effector Agrin (encoded by\n                    <jats:italic>Agrn<\/jats:italic>\n                    ), which was found to be predominantly expressed in endothelial cells. We further developed a targeted delivery system for nSC\u2010EVs, which significantly enhanced functional recovery, including motor and bladder control, in adult SCI mice. This work elucidates the mechanistic basis of age\u2010dependent repair processes and proposes a novel EV\u2010based therapy for SCI.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70371","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:10:54Z","timestamp":1791652254000},"source":"Crossref","is-referenced-by-count":0,"title":["Agrin\u2010Enriched Neonatal Spinal Cord\u2010Derived Extracellular Vesicles Bypass Age Barriers to Organize Spinal Cord Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Yongfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Xijing Hospital, Fourth Military Medical University  Xi'an People's Republic of China"},{"name":"Department of Neurology The First Affiliated Hospital of Xi'an Jiao Tong University  Xi'an People's Republic of 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People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhui","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xijing Hospital, Fourth Military Medical University  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xijing Hospital, Fourth Military Medical University  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xijing Hospital, Fourth Military Medical University  Xi'an People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xijing Hospital, Fourth Military Medical University  Xi'an 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